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Opaleye Management Portfolio holdings

AUM $1.1B
1-Year Est. Return 197.64%
This Fund
S&P 500
This Quarter Est. Return
-8.7%
1 Year Est. Return
+197.64%
3 Year Est. Return
+748.31%
5 Year Est. Return
+1,163.14%
10 Year Est. Return
+87,953.74%
AUM
$449M
AUM Growth
-$122M
Cap. Flow
-$33.8M
Cap. Flow %
-7.52%
Top 10 Hldgs %
73.91%
Holding
54
New
15
Increased
8
Reduced
14
Closed
9

Top Buys

Rank Stock Value
1
SNWV
SANUWAVE Health Inc
SNWV
+$31.9M
2
IMNM icon
Immunome
IMNM
+$14.5M
3
LQDA icon
Liquidia Corp
LQDA
+$8.2M
4
ANIK icon
Anika Therapeutics
ANIK
+$6.57M
5
LRMR icon
Larimar Therapeutics
LRMR
+$6.05M

Top Sells

Rank Stock Value
1
TGTX icon
TG Therapeutics
TGTX
+$58M
2
OCUL icon
Ocular Therapeutix
OCUL
+$21.1M
3
JSPR icon
Jasper Therapeutics
JSPR
+$8.55M
4
NAMS icon
NewAmsterdam Pharma
NAMS
+$8.35M
5
TRVI icon
Trevi Therapeutics
TRVI
+$7.26M

Sector Composition

Rank Sector Weight
1 Healthcare 97.58%
2 Miscellaneous 2.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RGNX icon
51
Regenxbio
RGNX
$619M
– –
-80,000
Closed -$618K
URGN icon
52
UroGen Pharma
URGN
$2.22B
– –
-220,000
Closed -$2.34M
1 2
3

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HBCM
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HAS
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Opaleye Management's Q1 2025 Portfolio in Review

As of Q1 2025, Opaleye Management held 54 positions worth $449M, down 21% from $571M the previous quarter. Its ten largest holdings account for 74% of the portfolio.

Opaleye Management withdrew a net $33.8M in Q1 2025, closing 9 positions and reducing 14 holdings. Its most notable exit was Jasper Therapeutics, an estimated $8.55M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 98% a quarter earlier, followed by Miscellaneous.

Against the trend, Opaleye Management opened a new position in SANUWAVE Health Inc worth $34.4M.

  • Opaleye Management's largest Q1 2025 buy was SANUWAVE Health Inc: 972,002 shares worth $34.4M.
  • Opaleye Management added most to Immunome in Q1 2025, an estimated $14.5M increase.
  • Opaleye Management's biggest Q1 2025 reduction was TG Therapeutics, cutting an estimated $58M.
  • Opaleye Management fully exited Jasper Therapeutics in Q1 2025, selling an estimated $8.55M.
  • Opaleye Management's ten largest holdings make up 74% of its $449M portfolio in Q1 2025.
  • Opaleye Management opened 15 new positions and closed 9 in Q1 2025.
  • Opaleye Management's portfolio value fell 21% quarter-over-quarter to $449M.

Based on Opaleye Management's 13F filing for Q1 2025, filed 15 May 2025.