OM

Opaleye Management Portfolio holdings

AUM $494M
This Quarter Return
-2.77%
1 Year Return
+68.17%
3 Year Return
+608.37%
5 Year Return
+807.76%
10 Year Return
+24,567.28%
AUM
$535M
AUM Growth
+$535M
Cap. Flow
+$12.7M
Cap. Flow %
2.38%
Top 10 Hldgs %
59.08%
Holding
57
New
9
Increased
13
Reduced
14
Closed
9

Top Buys

1
SMLR icon
Semler Scientific
SMLR
$28.2M
2
KROS icon
Keros Therapeutics
KROS
$4.65M
3
CRNX icon
Crinetics Pharmaceuticals
CRNX
$4.24M
4
FOLD icon
Amicus Therapeutics
FOLD
$3.06M
5
CMRX
Chimerix, Inc.
CMRX
$2.48M

Top Sells

1
EPIX icon
ESSA Pharma
EPIX
$8.12M
2
MCRB icon
Seres Therapeutics
MCRB
$5.96M
3
WGS icon
GeneDx Holdings
WGS
$5.24M
4
LUMO
Lumos Pharma, Inc. Common Stock
LUMO
$3.82M
5
KZR icon
Kezar Life Sciences
KZR
$3.79M

Sector Composition

1 Healthcare 98.44%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
DCPH
26
DELISTED
Deciphera Pharmaceuticals, Inc. Common Stock
DCPH
$6.98M 1.3%
205,381
– –
TELA icon
27
TELA Bio
TELA
$65.4M
$6.05M 1.13%
443,199
+2,734
+0.6% +$37.3K
PTGX icon
28
Protagonist Therapeutics
PTGX
$3.62B
$5.85M 1.09%
330,222
– –
AFIB
29
DELISTED
Acutus Medical, Inc. Common Stock
AFIB
$5.22M 0.97%
590,000
-9,990
-2% -$88.3K
OPTN
30
DELISTED
OptiNose
OPTN
$4.68M 0.87%
1,558,500
+331,900
+27% +$996K
MEIP icon
31
MEI Pharma
MEIP
$149M
$4.32M 0.81%
1,565,000
– –
FMTX
32
DELISTED
Forma Therapeutics Holdings, Inc. Common Stock
FMTX
$4.24M 0.79%
182,950
+11,950
+7% +$277K
SRRA
33
DELISTED
Sierra Oncology, Inc. Common Stock
SRRA
$3.63M 0.68%
165,778
+278
+0.2% +$6.09K
AVTX icon
34
Avalo Therapeutics
AVTX
$139M
$3.18M 0.59%
1,459,400
-108,094
-7% -$232K
FOLD icon
35
Amicus Therapeutics
FOLD
$2.42B
$3.06M 0.57%
+320,800
New +$3.06M
AVEO
36
DELISTED
AVEO Pharmaceuticals, Inc.
AVEO
$2.82M 0.53%
455,600
-191,400
-30% -$1.18M
MRUS icon
37
Merus
MRUS
$5.04B
$2.21M 0.41%
+100,250
New +$2.21M
VIRX
38
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$2.07M 0.39%
258,556
+1,367
+0.5% +$11K
SIOX
39
DELISTED
Sio Gene Therapies Inc. Common Stock
SIOX
$2.07M 0.39%
955,000
-1,045,000
-52% -$2.27M
LPTX icon
40
Leap Therapeutics
LPTX
$12M
$1.91M 0.36%
476,000
-64,000
-12% -$257K
DTIL icon
41
Precision BioSciences
DTIL
$59.5M
$1.89M 0.35%
+163,900
New +$1.89M
WHWK
42
Whitehawk Therapeutics, Inc. Common Stock
WHWK
$85.3M
$1.32M 0.25%
+45,020
New +$1.32M
NCNA
43
NuCana
NCNA
$5.8M
$1.24M 0.23%
+479,600
New +$1.24M
APTO
44
DELISTED
Aptose Biosciences, Inc.
APTO
$1.2M 0.22%
549,000
-431,000
-44% -$940K
AKBA icon
45
Akebia Therapeutics
AKBA
$827M
$897K 0.17%
+311,300
New +$897K
RNAC icon
46
Cartesian Therapeutics
RNAC
$267M
$441K 0.08%
+106,000
New +$441K
CBAY
47
DELISTED
Cymabay Therapeutics
CBAY
$420K 0.08%
+115,015
New +$420K
BLRX
48
BioLineRX
BLRX
$15.5M
$46K 0.01%
16,667
– –
CFRX
49
DELISTED
ContraFect Corporation
CFRX
– –
-57,900
Closed -$255K
LUMO
50
DELISTED
Lumos Pharma, Inc. Common Stock
LUMO
– –
-382,000
Closed -$3.82M
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