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Opaleye Management Portfolio holdings

AUM $1.1B
1-Year Est. Return 197.64%
This Fund
S&P 500
This Quarter Est. Return
+109.07%
1 Year Est. Return
+197.64%
3 Year Est. Return
+748.31%
5 Year Est. Return
+1,163.14%
10 Year Est. Return
+87,953.74%
AUM
$510M
AUM Growth
+$233M
Cap. Flow
+$45.1M
Cap. Flow %
8.85%
Top 10 Hldgs %
42.94%
Holding
56
New
7
Increased
29
Reduced
8
Closed
9

Top Buys

Rank Stock Value
1
APTO
Aptose Biosciences, Inc.
APTO
+$9.74M
2
OCUL icon
Ocular Therapeutix
OCUL
+$8.11M
3
FOCL
EDAP TMS S.A.
FOCL
+$6.97M
4
FLXN
Flexion Therapeutics, Inc.
FLXN
+$5.24M
5
ACHN
Achillion Pharmaceuticals
ACHN
+$4.4M

Top Sells

Rank Stock Value
1
TVRD
Tvardi Therapeutics
TVRD
+$8.04M
2
CYTK icon
Cytokinetics
CYTK
+$7.4M
3
SWAV
Shockwave Medical, Inc. Common Stock
SWAV
+$4.79M
4
THOR
Synthorx, Inc. Common Stock
THOR
+$2.93M
5
NXTC icon
NextCure
NXTC
+$2.62M

Sector Composition

Rank Sector Weight
1 Healthcare 98.07%
2 Miscellaneous 1.93%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FLXN
26
DELISTED
Flexion Therapeutics, Inc.
FLXN
$8.6M 1.69%
415,500
+310,500
+296% +$5.24M
BPMC
27
DELISTED
Blueprint Medicines
BPMC
$8M 1.57%
100,000
-5,000
-5% -$374K
ZYME icon
28
Zymeworks
ZYME
$2.07B
$7.96M 1.56%
175,000
+5,000
+3% +$182K
FOCL
29
EDAP TMS S.A.
FOCL
$199M
$7.91M 1.55%
1,785,000
+1,485,000
+495% +$6.97M
TCDA
30
DELISTED
Tricida, Inc. Common Stock
TCDA
$7.3M 1.43%
194,000
-1,000
-0.5% -$37.3K
DNTH icon
31
Dianthus Therapeutics
DNTH
$6.24B
$6.73M 1.32%
28,122
+4,059
+17% +$758K
CRNX icon
32
Crinetics Pharmaceuticals
CRNX
$9B
$6.68M 1.31%
266,100
+59,100
+29% +$1.13M
RARX
33
DELISTED
Ra Pharmaceuticals, Inc. Common Stock
RARX
$6.66M 1.31%
141,800
– –
TGTX icon
34
TG Therapeutics
TGTX
$8.53B
$6.43M 1.26%
579,651
-32,849
-5% -$250K
KYNB
35
Kyntra Bio
KYNB
$32.4M
$6.26M 1.23%
5,840
-160
-3% -$163K
ACHN
36
DELISTED
Achillion Pharmaceuticals
ACHN
$4.58M 0.9%
+760,000
New +$4.4M
AQST icon
37
Aquestive Therapeutics
AQST
$648M
$4.3M 0.84%
+738,500
New +$3.84M
KDMN
38
DELISTED
Kadmon Holdings, Inc.
KDMN
$4.26M 0.84%
+940,373
New +$3.44M
RDUS
39
DELISTED
Radius Health, Inc.
RDUS
$3.39M 0.66%
168,000
+93,000
+124% +$2.26M
QTRX icon
40
Quanterix
QTRX
$125M
$3.12M 0.61%
132,200
-52,800
-29% -$1.2M
RYTM icon
41
Rhythm Pharmaceuticals
RYTM
$7.75B
$2.54M 0.5%
+110,500
New +$2.45M
TELA icon
42
TELA Bio
TELA
$29.2M
$2.27M 0.44%
+175,000
New +$2.14M
MGNX icon
43
MacroGenics
MGNX
$260M
$2.18M 0.43%
+200,500
New +$1.98M
FENC icon
44
Fennec Pharmaceuticals
FENC
$413M
$78K 0.02%
+12,000
New +$64.5K
TARA icon
45
Protara Therapeutics
TARA
$236M
$75K 0.01%
4,704
+3,354
+248% +$38.5K
BLRX
46
BioLineRX
BLRX
$12.1M
$38K 0.01%
417
– –
ASMB icon
47
Assembly Biosciences
ASMB
$709M
– –
-4,167
Closed -$492K
CYTK icon
48
Cytokinetics
CYTK
$10.8B
– –
-650,000
Closed -$7.4M
NXTC icon
49
NextCure
NXTC
$27.6M
– –
-7,083
Closed -$2.62M
TVRD
50
Tvardi Therapeutics
TVRD
$24M
– –
-12,222
Closed -$8.04M
1
2
3

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Opaleye Management's Q4 2019 Portfolio in Review

As of Q4 2019, Opaleye Management held 56 positions worth $510M, up 84% from $277M the previous quarter. Its ten largest holdings account for 43% of the portfolio.

Opaleye Management deployed $45.1M of net new capital in Q4 2019, opening 7 new positions and adding to 29 existing holdings. Its largest new stake was Achillion Pharmaceuticals: 760,000 shares worth $4.58M.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Miscellaneous.

On the sell side, the largest reduction was Quanterix, an estimated $1.2M trimmed.

  • Opaleye Management's largest Q4 2019 buy was Achillion Pharmaceuticals: 760,000 shares worth $4.58M.
  • Opaleye Management added most to Aptose Biosciences, Inc. in Q4 2019, an estimated $9.74M increase.
  • Opaleye Management's biggest Q4 2019 reduction was Quanterix, cutting an estimated $1.2M.
  • Opaleye Management fully exited Tvardi Therapeutics in Q4 2019, selling an estimated $8.04M.
  • Opaleye Management's ten largest holdings make up 43% of its $510M portfolio in Q4 2019.
  • Opaleye Management opened 7 new positions and closed 9 in Q4 2019.
  • Opaleye Management's portfolio value rose 84% quarter-over-quarter to $510M.

Based on Opaleye Management's 13F filing for Q4 2019, filed 14 Feb 2020.