Main Street Research Portfolio holdings
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P Biotech ETF
XBI
|
+$41.3M |
| 2 |
Johnson & Johnson
JNJ
|
+$33.2M |
| 3 |
AstraZeneca
AZN
|
+$32.6M |
| 4 |
iShares MSCI South Korea ETF
EWY
|
+$32.5M |
| 5 |
Caterpillar
CAT
|
+$31.4M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Netflix
NFLX
|
+$45.1M |
| 2 |
T-Mobile US
TMUS
|
+$37.8M |
| 3 |
Mercado Libre
MELI
|
+$37M |
| 4 |
Spotify
SPOT
|
+$35.2M |
| 5 |
Trane Technologies
TT
|
+$32.1M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 35.88% |
| 2 | Financials | 16.32% |
| 3 | Communication Services | 9.11% |
| 4 | Healthcare | 7.73% |
| 5 | Consumer Staples | 6.59% |
Similar funds
Main Street Research's Q4 2025 Portfolio in Review
As of Q4 2025, Main Street Research held 146 positions worth $1.75B, down 5.5% from $1.85B the previous quarter. Its ten largest holdings account for 45% of the portfolio.
Main Street Research withdrew a net $128M in Q4 2025, closing 17 positions and reducing 77 holdings. Its most notable exit was Mercado Libre, an estimated $37M position sold in full.
By sector, the portfolio is most concentrated in Technology at 36% of assets, up from 36% a quarter earlier, followed by Financials and Communication Services.
Against the trend, Main Street Research opened a new position in State Street SPDR S&P Biotech ETF worth $44M.
- Main Street Research's largest Q4 2025 buy was State Street SPDR S&P Biotech ETF: 360,526 shares worth $44M.
- Main Street Research added most to Johnson & Johnson in Q4 2025, an estimated $33.2M increase.
- Main Street Research's biggest Q4 2025 reduction was Netflix, cutting an estimated $45.1M.
- Main Street Research fully exited Mercado Libre in Q4 2025, selling an estimated $37M.
- Main Street Research's ten largest holdings make up 45% of its $1.75B portfolio in Q4 2025.
- Main Street Research opened 17 new positions and closed 17 in Q4 2025.
- Main Street Research's portfolio value fell 5.5% quarter-over-quarter to $1.75B.
Based on Main Street Research's 13F filing for Q4 2025, filed 9 Feb 2026.