Main Street Research’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

Main Street Research’s Portfolio XBI Stock Details XBI Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$91.3M	Buy	576,754 +9,275	+2%	+$1.25M	4.31%	7
2026 Q1	$72.5M	Buy	567,479 +206,953	+57%	+$25.8M	4.22%	6
2025 Q4	$44M	Buy	+360,526	New	+$41.3M	2.51%	16

Other funds holding XBI

BNP Paribas Financial Markets Paris, France $289B AUM 60.46% 1-Year Est. Return

Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return

Citigroup New York $303B AUM 53.02% 1-Year Est. Return

Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.55T AUM 33.47% 1-Year Est. Return

Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $71.2B AUM 48.86% 1-Year Est. Return

Wells Fargo San Francisco, California $617B AUM 30.33% 1-Year Est. Return

UBS Group Zurich, Switzerland $786B AUM 40.34% 1-Year Est. Return

Barclays London, United Kingdom $521B AUM 51.41% 1-Year Est. Return

JFG

Jefferies Financial Group New York $15.2B AUM 55.75% 1-Year Est. Return

Main Street Research's XBI Position: Q2 2026 in Review

Main Street Research increased its State Street SPDR S&P Biotech ETF (XBI) stake by 1.6% in Q2 2026, buying an estimated $1.25M and bringing the position to 576,754 shares worth $91.3M. The position accounts for 4.31% of the portfolio, ranked #7.

Main Street Research first reported a position in XBI in Q4 2025 and has held it in 3 quarters since. 934 funds tracked by Wall St. Rank hold XBI as of Q2 2026.

Main Street Research held 576,754 shares of State Street SPDR S&P Biotech ETF worth $91.3M as of Q2 2026.
Main Street Research bought 9,275 State Street SPDR S&P Biotech ETF shares in Q2 2026, an estimated $1.25M.
State Street SPDR S&P Biotech ETF made up 4.31% of Main Street Research's portfolio in Q2 2026, its #7 holding.
Main Street Research first reported a position in State Street SPDR S&P Biotech ETF in Q4 2025 and has held it in 3 quarters since.
934 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q2 2026.

Based on Main Street Research's 13F filing for Q2 2026, filed 29 Jul 2026.