Jim Simons
OBIO icon

Jim Simons’s Orchestra BioMed OBIO Stock Holding History

Jim Simons’s Portfolio OBIO Stock Details OBIO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$301K Sell
70,900
-80,400
-53% -$342K ﹤0.01% 2789
2025
Q4 		$628K Sell
151,300
-229,208
-60% -$925K ﹤0.01% 2483
2025
Q3 		$944K Buy
380,508
+211,108
+125% +$582K ﹤0.01% 2509
2025
Q2 		$454K Buy
+169,400
New +$494K ﹤0.01% 2882
2023
Q3 		– Sell
-12,600
Closed -$88K – 3966
2023
Q2 		$88K Buy
+12,600
New +$191K ﹤0.01% 3504

Other funds holding OBIO

RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Alyeska Investment Group
Alyeska Investment Group Chicago, Illinois $35.4B AUM 33.54% 1-Year Est. Return
PBM
Propel Bio Management Los Angeles, California $159M AUM 60.94% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return
Charles Schwab
Charles Schwab San Francisco, California $654B AUM 26.35% 1-Year Est. Return

Jim Simons's OBIO Position: Q1 2026 in Review

Jim Simons reduced its Orchestra BioMed (OBIO) stake by 53% in Q1 2026, selling an estimated $342K and leaving 70,900 shares worth $301K. The position accounts for ﹤0.01% of the portfolio, ranked #2789.

Jim Simons first reported a position in OBIO in Q2 2023 and has held it in 5 quarters since. The position peaked at $944K in Q3 2025. 65 funds tracked by Wall St. Rank hold OBIO as of Q1 2026.

  • Jim Simons held 70,900 shares of Orchestra BioMed worth $301K as of Q1 2026.
  • Jim Simons sold 80,400 Orchestra BioMed shares in Q1 2026, an estimated $342K.
  • Orchestra BioMed made up ﹤0.01% of Jim Simons's portfolio in Q1 2026, its #2789 holding.
  • Jim Simons first reported a position in Orchestra BioMed in Q2 2023 and has held it in 5 quarters since.
  • Jim Simons's Orchestra BioMed position peaked at $944K in Q3 2025.
  • 65 funds tracked by Wall St. Rank held Orchestra BioMed as of Q1 2026.

Based on Renaissance Technologies's 13F filing for Q1 2026, filed 14 May 2026.