Jane Street’s Orchestra BioMed OBIO Stock Holding History

Jane Street’s Portfolio OBIO Stock Details OBIO Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$237K	Sell	55,680 -118,085	-68%	-$503K	﹤0.01%	9758
2025 Q4	$721K	Buy	173,765 +108,241	+165%	+$437K	﹤0.01%	6886
2025 Q3	$162K	Buy	65,524 +47,011	+254%	+$130K	﹤0.01%	9827
2025 Q2	$49.6K	Buy	+18,513	New	+$54K	﹤0.01%	9176
2024 Q4	–	Sell	-19,070	Closed	-$98K	–	10212
2024 Q3	$98K	Sell	19,070 -4,712	-20%	-$30.8K	﹤0.01%	8996
2024 Q2	$194K	Buy	+23,782	New	+$138K	﹤0.01%	8408

Other funds holding OBIO

RTW Investments New York $10B AUM 135.35% 1-Year Est. Return

Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Alyeska Investment Group Chicago, Illinois $35.4B AUM 33.54% 1-Year Est. Return

PBM

Propel Bio Management Los Angeles, California $159M AUM 60.94% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

AAA

Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return

Charles Schwab San Francisco, California $654B AUM 26.35% 1-Year Est. Return

Jane Street's OBIO Position: Q1 2026 in Review

Jane Street reduced its Orchestra BioMed (OBIO) stake by 68% in Q1 2026, selling an estimated $503K and leaving 55,680 shares worth $237K. The position accounts for ﹤0.01% of the portfolio, ranked #9758.

Jane Street first reported a position in OBIO in Q2 2024 and has held it in 6 quarters since. The position peaked at $721K in Q4 2025. 65 funds tracked by Wall St. Rank hold OBIO as of Q1 2026.

Jane Street held 55,680 shares of Orchestra BioMed worth $237K as of Q1 2026.
Jane Street sold 118,085 Orchestra BioMed shares in Q1 2026, an estimated $503K.
Orchestra BioMed made up ﹤0.01% of Jane Street's portfolio in Q1 2026, its #9758 holding.
Jane Street first reported a position in Orchestra BioMed in Q2 2024 and has held it in 6 quarters since.
Jane Street's Orchestra BioMed position peaked at $721K in Q4 2025.
65 funds tracked by Wall St. Rank held Orchestra BioMed as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.