II

Ishara Investments Portfolio holdings

AUM $99M
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
–
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$99M
AUM Growth
+$13.1M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
55
New
Increased
Reduced
Closed

Top Buys

1
+$7.08M
2
+$4.46M
3
+$3.53M
4
ARWR icon
Arrowhead Research
ARWR
+$3.5M
5
VSTM icon
Verastem
VSTM
+$3.39M

Top Sells

1
+$5.4M
2
+$3.58M
3
+$3.24M
4
BBIO icon
BridgeBio Pharma
BBIO
+$2.75M
5
UTHR icon
United Therapeutics
UTHR
+$2.68M

Sector Composition

1 Healthcare 100%
2 Industrials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PRAX icon
1
Praxis Precision Medicines
PRAX
$9.96B
$7.27M 7.34%
22,550
-17,450
AXSM icon
2
Axsome Therapeutics
AXSM
$12.1B
$6.93M 7%
+41,000
XERS icon
3
Xeris Biopharma Holdings
XERS
$1.08B
$5.95M 6%
1,025,000
+225,000
KALV icon
4
KalVista Pharmaceuticals
KALV
$1.43B
$5.57M 5.63%
+276,750
FOLD
5
DELISTED
Amicus Therapeutics
FOLD
$5.34M 5.39%
369,000
+9,000
BMRN icon
6
BioMarin Pharmaceuticals
BMRN
$10.1B
$4.63M 4.68%
82,000
-18,000
VSTM icon
7
Verastem
VSTM
$373M
$4.35M 4.39%
820,000
+550,000
RARE icon
8
Ultragenyx Pharmaceutical
RARE
$2.3B
$3.65M 3.69%
174,250
+124,250
ARWR icon
9
Arrowhead Research
ARWR
$11.1B
$3.47M 3.5%
+55,350
PCVX icon
10
Vaxcyte
PCVX
$7.37B
$3.34M 3.37%
57,400
+7,400
VERA icon
11
Vera Therapeutics
VERA
$2.46B
$3.3M 3.33%
+82,000
TVTX icon
12
Travere Therapeutics
TVTX
$4.44B
$3.29M 3.32%
+110,700
MLTX icon
13
MoonLake Immunotherapeutics
MLTX
$1.36B
$3.25M 3.28%
+174,250
ZNTL icon
14
Zentalis Pharmaceuticals
ZNTL
$286M
$2.88M 2.91%
1,230,000
-90,000
SRRK icon
15
Scholar Rock
SRRK
$6.07B
$2.82M 2.85%
+57,400
ACAD icon
16
Acadia Pharmaceuticals
ACAD
$3.63B
$2.74M 2.77%
123,000
-37,000
ARDX icon
17
Ardelyx
ARDX
$1.52B
$2.7M 2.73%
+451,000
MLYS icon
18
Mineralys Therapeutics
MLYS
$2.48B
$2.22M 2.24%
+82,000
GMAB icon
19
Genmab
GMAB
$16.4B
$2.2M 2.22%
82,000
+12,000
DBVT
20
DBV Technologies
DBVT
$1.09B
$2.14M 2.16%
+102,500
CPRX icon
21
Catalyst Pharmaceutical
CPRX
$3.83B
$2.03M 2.05%
+82,000
SION
22
Sionna Therapeutics
SION
$1.96B
$1.97M 1.99%
+49,200
CTNM
23
Contineum Therapeutics
CTNM
$502M
$1.85M 1.87%
+142,000
ALNY icon
24
Alnylam Pharmaceuticals
ALNY
$39.5B
$1.7M 1.71%
+5,125
LGND icon
25
Ligand Pharmaceuticals
LGND
$4.73B
$1.64M 1.65%
+8,200
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