II

Ishara Investments Portfolio holdings

AUM $99M
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
–
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$99M
AUM Growth
+$13.1M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
55
New
Increased
Reduced
Closed

Top Buys

1
+$7.08M
2
+$4.46M
3
+$3.53M
4
ARWR icon
Arrowhead Research
ARWR
+$3.5M
5
VSTM icon
Verastem
VSTM
+$3.39M

Top Sells

1
+$5.4M
2
+$3.58M
3
+$3.24M
4
BBIO icon
BridgeBio Pharma
BBIO
+$2.75M
5
UTHR icon
United Therapeutics
UTHR
+$2.68M

Sector Composition

1 Healthcare 100%
2 Industrials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
EWTX icon
26
Edgewise Therapeutics
EWTX
$3.61B
$1.55M 1.57%
49,200
-8,800
IMTX icon
27
Immatics
IMTX
$1.56B
$1.51M 1.53%
153,750
+73,750
LXRX icon
28
Lexicon Pharmaceuticals
LXRX
$964M
$1.41M 1.42%
902,000
+22,000
BEAM icon
29
Beam Therapeutics
BEAM
$3.28B
$1.37M 1.38%
57,400
+7,400
ORIC icon
30
Oric Pharmaceuticals
ORIC
$888M
$1.3M 1.31%
102,500
-57,500
NAMS icon
31
NewAmsterdam Pharma
NAMS
$4.27B
$1.18M 1.19%
36,900
+6,900
ANNX icon
32
Annexon
ANNX
$883M
$965K 0.97%
174,250
-575,750
IDYA icon
33
IDEAYA Biosciences
IDYA
$2.57B
$820K 0.83%
+24,600
SLN
34
Silence Therapeutics
SLN
$321M
$740K 0.75%
140,500
-99,500
PTCT icon
35
PTC Therapeutics
PTCT
$5.86B
$698K 0.71%
10,250
-25,750
GOSS icon
36
Gossamer Bio
GOSS
$51.1M
$269K 0.27%
+820,000
AGIO icon
37
Agios Pharmaceuticals
AGIO
$1.7B
– –
-30,000
APLS
38
DELISTED
Apellis Pharmaceuticals
APLS
– –
-50,000
APOG icon
39
Apogee Enterprises
APOG
$803M
– –
-25,000
ARQT icon
40
Arcutis Biotherapeutics
ARQT
$2.65B
– –
-12,000
ASND icon
41
Ascendis Pharma A/S
ASND
$14.5B
– –
-5,000
BBIO icon
42
BridgeBio Pharma
BBIO
$13B
– –
-36,000
BCRX icon
43
BioCryst Pharmaceuticals
BCRX
$2.32B
– –
-300,000
BHVN icon
44
Biohaven
BHVN
$1.7B
– –
-88,000
CORT icon
45
Corcept Therapeutics
CORT
$7.15B
– –
0
DNLI icon
46
Denali Therapeutics
DNLI
$3.21B
– –
-70,000
DNTH icon
47
Dianthus Therapeutics
DNTH
$4.74B
– –
-24,000
IMVT icon
48
Immunovant
IMVT
$6.86B
– –
-30,000
INSM icon
49
Insmed
INSM
$23.1B
– –
-10,000
NKTR icon
50
Nektar Therapeutics
NKTR
$2.21B
– –
-20,000
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