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FCMI

Foresite Capital Management IV Portfolio holdings

AUM $237M
1-Year Est. Return 107.53%
This Fund
S&P 500
This Quarter Est. Return
+25.09%
1 Year Est. Return
+107.53%
3 Year Est. Return
+149.4%
5 Year Est. Return
+13.8%
10 Year Est. Return
–
AUM
$230M
AUM Growth
+$47.1M
Cap. Flow
+$6.9M
Cap. Flow %
3%
Top 10 Hldgs %
100%
Holding
7
New
1
Increased
–
Reduced
–
Closed
–

Top Buys

Rank Stock Value
1
ALEC icon
Alector
ALEC
+$6.9M

Top Sells

No sells this quarter

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PHVS icon
1
Pharvaris
PHVS
$2.39B
$133M 57.73%
4,778,581
– –
CYTK icon
2
Cytokinetics
CYTK
$11B
$29.1M 12.68%
458,295
– –
LYEL icon
3
Lyell Immunopharma
LYEL
$309M
$24.6M 10.72%
800,399
– –
MAZE
4
Maze Therapeutics
MAZE
$1.53B
$21.7M 9.43%
522,657
– –
RLAY icon
5
Relay Therapeutics
RLAY
$4.02B
$8.46M 3.68%
1,000,000
– –
XENE icon
6
Xenon Pharmaceuticals
XENE
$6.32B
$7.17M 3.12%
160,000
– –
ALEC icon
7
Alector
ALEC
$164M
$6.06M 2.64%
+3,887,200
New +$6.9M

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Foresite Capital Management IV's Q4 2025 Portfolio in Review

As of Q4 2025, Foresite Capital Management IV held 7 positions worth $230M, up 26% from $183M the previous quarter. Its ten largest holdings account for 100% of the portfolio.

Foresite Capital Management IV deployed $6.9M of net new capital in Q4 2025, opening 1 new position. Its largest new stake was Alector: 3,887,200 shares worth $6.06M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

  • Foresite Capital Management IV's largest Q4 2025 buy was Alector: 3,887,200 shares worth $6.06M.
  • Foresite Capital Management IV's ten largest holdings make up 100% of its $230M portfolio in Q4 2025.
  • Foresite Capital Management IV opened 1 new position and closed 0 in Q4 2025.
  • Foresite Capital Management IV's portfolio value rose 26% quarter-over-quarter to $230M.

Based on Foresite Capital Management IV's 13F filing for Q4 2025, filed 17 Feb 2026.