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FP

Flagship Pioneering Portfolio holdings

AUM $1.16B
1-Year Est. Return 67.93%
This Fund
S&P 500
This Quarter Est. Return
+34.9%
1 Year Est. Return
+67.93%
3 Year Est. Return
-39.17%
5 Year Est. Return
-45.89%
10 Year Est. Return
–
AUM
$3.13B
AUM Growth
+$756M
Cap. Flow
+$10.8M
Cap. Flow %
0.34%
Top 10 Hldgs %
99.84%
Holding
12
New
–
Increased
1
Reduced
–
Closed
–

Top Buys

Rank Stock Value
1
AXLA
Axcella Health Inc. Common Stock
AXLA
+$10.8M

Top Sells

No sells this quarter

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MRNA icon
1
Moderna
MRNA
$21.5B
$2.31B 73.9%
12,886,743
– –
OMGA
2
DELISTED
Omega Therapeutics, Inc. Common Stock
OMGA
$293M 9.37%
25,902,269
– –
SANA icon
3
Sana Biotechnology
SANA
$885M
$135M 4.32%
34,239,018
– –
MCRB icon
4
Seres Therapeutics
MCRB
$48.1M
$129M 4.13%
1,155,852
– –
EVLO
5
DELISTED
Evelo Biosciences, Inc. Common Stock
EVLO
$81.2M 2.59%
2,521,366
– –
FHTX icon
6
Foghorn Therapeutics
FHTX
$285M
$80.9M 2.58%
12,674,120
– –
DNLI icon
7
Denali Therapeutics
DNLI
$3.67B
$72.9M 2.33%
2,619,968
– –
AXLA
8
DELISTED
Axcella Health Inc. Common Stock
AXLA
$9.36M 0.3%
1,170,062
+415,351
+55% +$10.8M
RUBY
9
DELISTED
Rubius Therapeutics, Inc
RUBY
$6.55M 0.21%
38,506,526
– –
SGTX
10
DELISTED
Sigilon Therapeutics, Inc. Common Stock
SGTX
$3.63M 0.12%
797,721
– –
SYRS
11
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$3.57M 0.11%
993,848
– –
CDAK
12
DELISTED
Codiak BioSciences, Inc. Common Stock
CDAK
$1.38M 0.04%
3,540,636
– –

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BI
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SCP
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SFG
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GAB
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AMI
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FFP
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MI
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Flagship Pioneering's Q4 2022 Portfolio in Review

As of Q4 2022, Flagship Pioneering held 12 positions worth $3.13B, up 32% from $2.38B the previous quarter. Its ten largest holdings account for 100% of the portfolio.

Trading was light in Q4 2022: portfolio turnover was 0%. Flagship Pioneering opened no new positions and made no exits, leaving the 12-position portfolio largely intact.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

  • Flagship Pioneering added most to Axcella Health Inc. Common Stock in Q4 2022, an estimated $10.8M increase.
  • Flagship Pioneering's ten largest holdings make up 100% of its $3.13B portfolio in Q4 2022.
  • Flagship Pioneering opened 0 new positions and closed 0 in Q4 2022.
  • Flagship Pioneering's portfolio value rose 32% quarter-over-quarter to $3.13B.

Based on Flagship Pioneering's 13F filing for Q4 2022, filed 14 Feb 2023.