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DCM

Driehaus Capital Management Portfolio holdings

AUM $13.6B
1-Year Est. Return 173.98%
This Fund
S&P 500
This Quarter Est. Return
+28.72%
1 Year Est. Return
+173.98%
3 Year Est. Return
+706.72%
5 Year Est. Return
+1,585.86%
10 Year Est. Return
+31,592.09%
AUM
$14.7B
AUM Growth
+$761M
Cap. Flow
-$934M
Cap. Flow %
-6.35%
Top 10 Hldgs %
16.56%
Holding
518
New
87
Increased
137
Reduced
150
Closed
114

Top Buys

Rank Stock Value
1
EOSE icon
Eos Energy Enterprises
EOSE
+$111M
2
RMBS icon
Rambus
RMBS
+$93.9M
3
PRAX icon
Praxis Precision Medicines
PRAX
+$80.5M
4
FMX icon
Fomento Económico Mexicano
FMX
+$65.4M
5
NU icon
Nu Holdings
NU
+$59.3M

Top Sells

Rank Stock Value
1
ALAB icon
Astera Labs
ALAB
+$138M
2
CVLT icon
Commault Systems
CVLT
+$120M
3
PL icon
Planet Labs
PL
+$84M
4
OLLI icon
Ollie's Bargain Outlet
OLLI
+$76.8M
5
CRDO icon
Credo Technology Group
CRDO
+$75.9M

Sector Composition

Rank Sector Weight
1 Healthcare 29.41%
2 Industrials 21.41%
3 Technology 18.1%
4 Consumer Discretionary 9.17%
5 Financials 9.13%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ARWR icon
26
Arrowhead Research
ARWR
$12B
$117M 0.8%
1,769,340
-330,058
-16% -$16.2M
GPCR icon
27
Structure Therapeutics
GPCR
$3.37B
$114M 0.78%
1,642,444
+768,940
+88% +$31.4M
WVE icon
28
Wave Life Sciences
WVE
$1.11B
$112M 0.76%
6,581,067
+283,007
+4% +$2.88M
FN icon
29
Fabrinet
FN
$15B
$110M 0.75%
240,978
-132,458
-35% -$57.6M
WFRD icon
30
Weatherford International
WFRD
$5.98B
$108M 0.74%
1,384,142
+419,961
+44% +$30.5M
UEC icon
31
Uranium Energy
UEC
$4.51B
$106M 0.72%
9,112,072
-375,744
-4% -$4.93M
EWTX icon
32
Edgewise Therapeutics
EWTX
$4.3B
$104M 0.71%
4,191,193
+1,962,908
+88% +$39.4M
EMBJ
33
Embraer S.A. ADS
EMBJ
$12.1B
$102M 0.7%
1,590,028
+661,071
+71% +$41.4M
KRMN
34
Karman Holdings
KRMN
$6.26B
$99.2M 0.67%
1,355,169
-198,479
-13% -$14.4M
PTGX icon
35
Protagonist Therapeutics
PTGX
$8.64B
$96M 0.65%
1,099,170
-40,684
-4% -$3.33M
TARS icon
36
Tarsus Pharmaceuticals
TARS
$2.51B
$96M 0.65%
1,172,427
+141,386
+14% +$10.6M
CVNA icon
37
Carvana
CVNA
$48.7B
$95.8M 0.65%
1,134,815
-454,725
-29% -$33.8M
SYRE icon
38
Spyre Therapeutics
SYRE
$8.45B
$94.4M 0.64%
2,882,420
+822,045
+40% +$21.5M
CR icon
39
Crane Co
CR
$12.1B
$93.3M 0.63%
505,668
-32,677
-6% -$6.06M
EYE icon
40
National Vision
EYE
$1.77B
$93.1M 0.63%
3,606,811
+1,350,811
+60% +$36.3M
VSEC icon
41
VSE Corp
VSEC
$5.29B
$89.9M 0.61%
520,237
+182,544
+54% +$31.2M
RMBS icon
42
Rambus
RMBS
$9.23B
$87.7M 0.6%
+954,164
New +$93.9M
DFTX
43
Definium Therapeutics
DFTX
$5.61B
$87.5M 0.59%
6,537,202
+3,427,291
+110% +$42.4M
TMDX icon
44
Transmedics
TMDX
$2.68B
$86.6M 0.59%
712,041
-26,117
-4% -$3.28M
PTCT icon
45
PTC Therapeutics
PTCT
$6.2B
$86.3M 0.59%
1,136,188
+4,439
+0.4% +$323K
SRRK icon
46
Scholar Rock
SRRK
$5.88B
$86M 0.58%
1,952,877
-71,082
-4% -$2.67M
SPXC icon
47
SPX Corp
SPXC
$9.54B
$86M 0.58%
429,764
+154,388
+56% +$31.5M
ITUB icon
48
Itaú Unibanco
ITUB
$90.2B
$84.9M 0.58%
11,857,114
+948,720
+9% +$6.75M
KYMR icon
49
Kymera Therapeutics
KYMR
$8.74B
$83.2M 0.57%
1,069,238
+130,144
+14% +$8.79M
COHR icon
50
Coherent
COHR
$43.9B
$82.7M 0.56%
447,945
+9,093
+2% +$1.36M
1
2
3 4 5

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Driehaus Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Driehaus Capital Management held 518 positions worth $14.7B, up 5.4% from $14B the previous quarter. Its ten largest holdings account for 17% of the portfolio.

Driehaus Capital Management withdrew a net $934M in Q4 2025, closing 114 positions and reducing 150 holdings. Its most notable exit was Commault Systems, an estimated $120M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 29% of assets, up from 20% a quarter earlier, followed by Industrials and Technology.

Against the trend, Driehaus Capital Management opened a new position in Rambus worth $87.7M.

  • Driehaus Capital Management's largest Q4 2025 buy was Rambus: 954,164 shares worth $87.7M.
  • Driehaus Capital Management added most to Eos Energy Enterprises in Q4 2025, an estimated $111M increase.
  • Driehaus Capital Management's biggest Q4 2025 reduction was Astera Labs, cutting an estimated $138M.
  • Driehaus Capital Management fully exited Commault Systems in Q4 2025, selling an estimated $120M.
  • Driehaus Capital Management's ten largest holdings make up 17% of its $14.7B portfolio in Q4 2025.
  • Driehaus Capital Management opened 87 new positions and closed 114 in Q4 2025.
  • Driehaus Capital Management's portfolio value rose 5.4% quarter-over-quarter to $14.7B.

Based on Driehaus Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.