DS
SION

David Shaw’s Sionna Therapeutics SION Stock Holding History

David Shaw’s Portfolio SION Stock Details SION Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$4.47M Buy
+101,644
New +$4.07M ﹤0.01% 2499
2026
Q1 		– Sell
-5,742
Closed -$236K – 5179
2025
Q4 		$236K Buy
+5,742
New +$218K ﹤0.01% 4264

Other funds holding SION

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGA
TPG GP A Fort Worth, Texas $5B AUM 58.56% 1-Year Est. Return
Viking Global Investors
Viking Global Investors Stamford, Connecticut $35.1B AUM 21.36% 1-Year Est. Return
AVLSA
Atlas Venture Life Science Advisors Cambridge, Massachusetts $881M AUM 160.77% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
Jennison Associates
Jennison Associates New York $167B AUM 44.17% 1-Year Est. Return

David Shaw's SION Position: Q2 2026 in Review

David Shaw opened a new position in Sionna Therapeutics (SION) in Q2 2026: 101,644 shares worth $4.47M. The stake represents ﹤0.01% of the portfolio and ranks #2499 among its holdings. This is a return to the name: David Shaw previously reported a position in SION as recently as Q4 2025.

David Shaw first reported a position in SION in Q4 2025 and has held it in 2 quarters since. 146 funds tracked by Wall St. Rank hold SION as of Q2 2026.

  • David Shaw held 101,644 shares of Sionna Therapeutics worth $4.47M as of Q2 2026.
  • Sionna Therapeutics was a new David Shaw position in Q2 2026.
  • Sionna Therapeutics made up ﹤0.01% of David Shaw's portfolio in Q2 2026, its #2499 holding.
  • David Shaw first reported a position in Sionna Therapeutics in Q4 2025 and has held it in 2 quarters since.
  • 146 funds tracked by Wall St. Rank held Sionna Therapeutics as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.