D.E. Shaw & Co Portfolio holdings
D. E. Shaw & Co., L.P., founded in 1988 by David E. Shaw, a former Columbia University computer science professor, is a New York City-based global investment management firm renowned for pioneering quantitative investing, managing over $70 billion in assets as of late 2024. Starting with $28 million from Paloma Partners and private investors, the firm employs sophisticated mathematical models and proprietary algorithms—initially developed by a team of scientists and programmers—to exploit market anomalies across public and private markets, including equities, fixed income, and alternatives. Headquartered above a Greenwich Village bookstore in its early days, it now boasts over 2,500 employees across offices in North America, Europe, and Asia, led by a seven-member Executive Committee since Shaw stepped back in 2001 to focus on D. E. Shaw Research. Despite setbacks like the 1998 Russia debt crisis and the 2008 financial downturn, the firm has maintained a reputation for analytical rigor, risk management, and innovation, balancing its computational roots with discretionary strategies.
Top Buys
| 1 |
Advanced Micro Devices
AMD
|
+$1.52B |
| 2 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$1.43B |
| 3 |
iShares Core S&P 500 ETF
IVV
|
+$798M |
| 4 |
Amazon
AMZN
|
+$646M |
| 5 |
Texas Instruments
TXN
|
+$619M |
Top Sells
| 1 |
Micron Technology
MU
|
+$1.31B |
| 2 |
Broadcom
AVGO
|
+$1.01B |
| 3 |
Vanguard Intermediate-Term Corporate Bond ETF
VCIT
|
+$863M |
| 4 |
Western Digital
WDC
|
+$595M |
| 5 |
Meta Platforms (Facebook)
META
|
+$591M |
Sector Composition
| 1 | Technology | 18.6% |
| 2 | Consumer Discretionary | 9.12% |
| 3 | Healthcare | 7.62% |
| 4 | Industrials | 7.14% |
| 5 | Financials | 6.8% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
4076
Dakota Gold
DC
$558M
| $278K | ﹤0.01% |
+48,947
| New | +$235K |
|
4077
Compass Therapeutics
CMPX
$369M
| $276K | ﹤0.01% |
+51,482
| New | +$238K |
|
|
HUYA
4078
Huya Inc
HUYA
$551M
| $275K | ﹤0.01% |
95,602
+84,625
| +771% | +$248K |
|
4079
QCR Holdings
QCRH
$1.63B
| $274K | ﹤0.01% |
3,293
| – | – |
|
4080
CALL
Asana
ASAN
$1.77B
| $274K | ﹤0.01% |
20,000
-3,000
| -13% | -$41.2K |
|
4081
DXP Enterprises
DXPE
$2.6B
| $274K | ﹤0.01% |
2,494
-2,375
| -49% | -$259K |
|
4082
Alaska Air
ALK
$5.07B
| $273K | ﹤0.01% |
5,434
-147,015
| -96% | -$6.8M |
|
4083
GSK
GSK
$104B
| $272K | ﹤0.01% |
+5,544
| New | +$259K |
|
|
ONT
4084
Onterris Inc
ONT
$756M
| $272K | ﹤0.01% |
+10,944
| New | +$289K |
|
4085
Health Catalyst
HCAT
$166M
| $272K | ﹤0.01% |
113,641
+36,981
| +48% | +$101K |
|
4086
CALL
Darling Ingredients
DAR
$10B
| $270K | ﹤0.01% |
+7,500
| New | +$254K |
|
4087
CALL
uniQure
QURE
$2.77B
| $268K | ﹤0.01% |
11,200
-130,000
| -92% | -$5.02M |
|
|
SLNO
4088
DELISTED
Soleno Therapeutics
SLNO
| $267K | ﹤0.01% |
5,767
-1,999
| -26% | -$110K |
|
|
DAY
4089
DELISTED
Dayforce
DAY
| $267K | ﹤0.01% |
3,860
-44,468
| -92% | -$3.06M |
|
4090
AbCellera Biologics
ABCL
$1.97B
| $266K | ﹤0.01% |
77,776
+1,293
| +2% | +$5.77K |
|
4091
Inspired Entertainment
INSE
$174M
| $265K | ﹤0.01% |
28,345
-14,702
| -34% | -$124K |
|
4092
PUT
Alkami Technology
ALKT
$1.92B
| $265K | ﹤0.01% |
11,500
| – | – |
|
4093
US Physical Therapy
USPH
$1.12B
| $265K | ﹤0.01% |
3,392
-41,194
| -92% | -$3.34M |
|
4094
PUT
Zoetis
ZTS
$32.1B
| $264K | ﹤0.01% |
+2,100
| New | +$274K |
|
4095
Franklin FTSE China ETF
FLCH
$261M
| $264K | ﹤0.01% |
+11,087
| New | +$276K |
|
4096
Vanguard FTSE Europe ETF
VGK
$30B
| $263K | ﹤0.01% |
3,147
-1,107
| -26% | -$90K |
|
4097
iShares Global Consumer Staples ETF
KXI
$1.05B
| $263K | ﹤0.01% |
+4,068
| New | +$264K |
|
|
MPT
4098
Medical Properties Trust
MPT
$2.84B
| $263K | ﹤0.01% |
+52,588
| New | +$274K |
|
4099
CALL
SentinelOne
S
$6.71B
| $263K | ﹤0.01% |
17,500
-5,600
| -24% | -$91.7K |
|
4100
LSB Industries
LXU
$819M
| $262K | ﹤0.01% |
30,882
-16,342
| -35% | -$144K |
|
Similar funds
D.E. Shaw & Co's Q4 2025 Portfolio in Review
As of Q4 2025, D.E. Shaw & Co held 5,141 positions worth $182B, up 3% from $177B the previous quarter. Its ten largest holdings account for 12% of the portfolio.
D.E. Shaw & Co's Q4 2025 filing shows 639 new, 1,734 increased, 1,574 reduced and 583 closed positions. Its largest new stake was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M. The largest sale was Micron Technology, an estimated $1.31B.
By sector, the portfolio is most concentrated in Technology at 19% of assets, down from 19% a quarter earlier, followed by Consumer Discretionary and Healthcare.
- D.E. Shaw & Co's largest Q4 2025 buy was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M.
- D.E. Shaw & Co added most to Advanced Micro Devices in Q4 2025, an estimated $1.52B increase.
- D.E. Shaw & Co's biggest Q4 2025 reduction was Micron Technology, cutting an estimated $1.31B.
- D.E. Shaw & Co fully exited Vanguard Short-Term Corporate Bond ETF in Q4 2025, selling an estimated $499M.
- D.E. Shaw & Co's ten largest holdings make up 12% of its $182B portfolio in Q4 2025.
- D.E. Shaw & Co opened 639 new positions and closed 583 in Q4 2025.
- D.E. Shaw & Co's portfolio value rose 3% quarter-over-quarter to $182B.
Based on D.E. Shaw & Co's 13F filing for Q4 2025, filed 17 Feb 2026.