D.E. Shaw & Co
SION

D.E. Shaw & Co’s Sionna Therapeutics SION Stock Holding History

D.E. Shaw & Co’s Portfolio SION Stock Details SION Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$4.47M Buy
+101,644
New +$4.07M ﹤0.01% 2499
2026
Q1 		– Sell
-5,742
Closed -$236K – 5179
2025
Q4 		$236K Buy
+5,742
New +$218K ﹤0.01% 4264

Other funds holding SION

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGA
TPG GP A Fort Worth, Texas $5B AUM 58.56% 1-Year Est. Return
Viking Global Investors
Viking Global Investors Stamford, Connecticut $35.1B AUM 21.36% 1-Year Est. Return
AVLSA
Atlas Venture Life Science Advisors Cambridge, Massachusetts $881M AUM 160.77% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
Jennison Associates
Jennison Associates New York $167B AUM 44.17% 1-Year Est. Return

D.E. Shaw & Co's SION Position: Q2 2026 in Review

D.E. Shaw & Co opened a new position in Sionna Therapeutics (SION) in Q2 2026: 101,644 shares worth $4.47M. The stake represents ﹤0.01% of the portfolio and ranks #2499 among its holdings. This is a return to the name: D.E. Shaw & Co previously reported a position in SION as recently as Q4 2025.

D.E. Shaw & Co first reported a position in SION in Q4 2025 and has held it in 2 quarters since. 146 funds tracked by Wall St. Rank hold SION as of Q2 2026.

  • D.E. Shaw & Co held 101,644 shares of Sionna Therapeutics worth $4.47M as of Q2 2026.
  • Sionna Therapeutics was a new D.E. Shaw & Co position in Q2 2026.
  • Sionna Therapeutics made up ﹤0.01% of D.E. Shaw & Co's portfolio in Q2 2026, its #2499 holding.
  • D.E. Shaw & Co first reported a position in Sionna Therapeutics in Q4 2025 and has held it in 2 quarters since.
  • 146 funds tracked by Wall St. Rank held Sionna Therapeutics as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.