D.E. Shaw & Co
NUVL

D.E. Shaw & Co’s Nuvalent NUVL Stock Holding History

D.E. Shaw & Co’s Portfolio NUVL Stock Details NUVL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-27,311
Closed -$2.36M – 4876
2025
Q3 		$2.36M Sell
27,311
-129,477
-83% -$10.2M ﹤0.01% 2846
2025
Q2 		$12M Buy
156,788
+25,827
+20% +$1.89M 0.01% 1356
2025
Q1 		$9.29M Sell
130,961
-45,951
-26% -$3.59M 0.01% 1461
2024
Q4 		$13.8M Sell
176,912
-68,669
-28% -$6.41M 0.01% 1280
2024
Q3 		$25.1M Sell
245,581
-153,618
-38% -$12.7M 0.02% 869
2024
Q2 		$30.3M Sell
399,199
-46,183
-10% -$3.29M 0.03% 666
2024
Q1 		$33.4M Sell
445,382
-22,801
-5% -$1.81M 0.03% 644
2023
Q4 		$34.5M Buy
468,183
+150,907
+48% +$9.34M 0.03% 621
2023
Q3 		$14.6M Buy
317,276
+24,481
+8% +$1.09M 0.02% 1039
2023
Q2 		$12.3M Buy
292,795
+80,584
+38% +$3.05M 0.01% 1177
2023
Q1 		$5.54M Sell
212,211
-42,657
-17% -$1.26M 0.01% 1844
2022
Q4 		$7.59M Buy
254,868
+195,733
+331% +$5.46M 0.01% 1692
2022
Q3 		$1.15M Buy
59,135
+42,642
+259% +$714K ﹤0.01% 3490
2022
Q2 		$224K Buy
+16,493
New +$175K ﹤0.01% 4498
2021
Q4 		– Sell
-12,142
Closed -$274K – 5608
2021
Q3 		$274K Buy
+12,142
New +$352K ﹤0.01% 4409

Other funds holding NUVL

DM
Deerfield Management New York $8.48B AUM 99.04% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

D.E. Shaw & Co's NUVL Position: Q4 2025 in Review

D.E. Shaw & Co sold out of Nuvalent (NUVL) in Q4 2025, closing a stake of 27,311 shares — an estimated $2.36M sold.

D.E. Shaw & Co first reported a position in NUVL in Q3 2021 and held it in 15 quarters. The position peaked at $34.5M in Q4 2023. 237 funds tracked by Wall St. Rank hold NUVL as of Q4 2025.

  • D.E. Shaw & Co reported no remaining Nuvalent position as of Q4 2025 after selling out during the quarter.
  • D.E. Shaw & Co sold 27,311 Nuvalent shares in Q4 2025, an estimated $2.36M.
  • D.E. Shaw & Co first reported a position in Nuvalent in Q3 2021 and held it in 15 quarters.
  • D.E. Shaw & Co's Nuvalent position peaked at $34.5M in Q4 2023.
  • 237 funds tracked by Wall St. Rank held Nuvalent as of Q4 2025.

Based on D.E. Shaw & Co's 13F filing for Q4 2025, filed 17 Feb 2026.