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Checkpoint Capital Portfolio holdings

AUM $279M
1-Year Est. Return 45.74%
This Fund
S&P 500
This Quarter Est. Return
+14.16%
1 Year Est. Return
+45.74%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$320M
AUM Growth
+$21.6M
Cap. Flow
+$5.51M
Cap. Flow %
1.72%
Top 10 Hldgs %
100%
Holding
11
New
1
Increased
4
Reduced
2
Closed
4

Top Buys

Rank Stock Value
1
RYTM icon
Rhythm Pharmaceuticals
RYTM
+$24.2M
2
CYTK icon
Cytokinetics
CYTK
+$8.04M
3
IRON icon
Disc Medicine
IRON
+$1.94M
4
CORT icon
Corcept Therapeutics
CORT
+$712K

Top Sells

Rank Stock Value
1
CRNX icon
Crinetics Pharmaceuticals
CRNX
+$10.8M
2
RVMD icon
Revolution Medicines
RVMD
+$8.02M
3
ARGX icon
argenx
ARGX
+$6.85M
4
SEPN
Septerna Inc
SEPN
+$5.33M
5
STOK icon
Stoke Therapeutics
STOK
+$4.98M

Sector Composition

Rank Sector Weight
1 Healthcare 98.61%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ARGX icon
1
argenx
ARGX
$53.4B
$119M 37.31%
142,000
-8,000
-5% -$6.85M
RYTM icon
2
Rhythm Pharmaceuticals
RYTM
$6.81B
$106M 33.18%
992,200
+228,493
+30% +$24.2M
IRON icon
3
Disc Medicine
IRON
$2.96B
$36M 11.24%
452,992
+22,992
+5% +$1.94M
RVMD icon
4
Revolution Medicines
RVMD
$39.9B
$29.5M 9.21%
370,000
-122,300
-25% -$8.02M
CORT icon
5
Corcept Therapeutics
CORT
$12.4B
$14M 4.36%
401,395
+9,064
+2% +$712K
CYTK icon
6
Cytokinetics
CYTK
$10.5B
$10.6M 3.31%
166,823
+129,236
+344% +$8.04M
CORT icon
7
CALL
Corcept Therapeutics
CORT
$12.4B
$4.46M 1.39%
+128,300
New +$10.1M
CRNX icon
8
Crinetics Pharmaceuticals
CRNX
$8.84B
– –
-260,000
Closed -$10.8M
KYMR icon
9
Kymera Therapeutics
KYMR
$8.51B
– –
-61,750
Closed -$3.5M
STOK icon
10
Stoke Therapeutics
STOK
$1.8B
– –
-212,049
Closed -$4.98M
SEPN
11
Septerna Inc
SEPN
$1.55B
– –
-283,158
Closed -$5.33M

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Checkpoint Capital's Q4 2025 Portfolio in Review

As of Q4 2025, Checkpoint Capital held 11 positions worth $320M, up 7.2% from $298M the previous quarter. Its ten largest holdings account for 100% of the portfolio.

Checkpoint Capital's Q4 2025 filing shows 1 new, 4 increased, 2 reduced and 4 closed positions. The largest sale was Crinetics Pharmaceuticals, an estimated $10.8M.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, down from 100% a quarter earlier.

  • Checkpoint Capital added most to Rhythm Pharmaceuticals in Q4 2025, an estimated $24.2M increase.
  • Checkpoint Capital's biggest Q4 2025 reduction was Revolution Medicines, cutting an estimated $8.02M.
  • Checkpoint Capital fully exited Crinetics Pharmaceuticals in Q4 2025, selling an estimated $10.8M.
  • Checkpoint Capital's ten largest holdings make up 100% of its $320M portfolio in Q4 2025.
  • Checkpoint Capital opened 1 new position and closed 4 in Q4 2025.
  • Checkpoint Capital's portfolio value rose 7.2% quarter-over-quarter to $320M.

Based on Checkpoint Capital's 13F filing for Q4 2025, filed 17 Feb 2026.