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Braidwell Portfolio holdings

AUM $3B
1-Year Est. Return 46.72%
This Fund
S&P 500
This Quarter Est. Return
+10.55%
1 Year Est. Return
+46.72%
3 Year Est. Return
+56.07%
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.37B
AUM Growth
+$446M
Cap. Flow
-$654M
Cap. Flow %
-19.4%
Top 10 Hldgs %
44.1%
Holding
79
New
25
Increased
8
Reduced
18
Closed
6

Top Buys

Rank Stock Value
1
SLNO
Soleno Therapeutics
SLNO
+$95M
2
ACAD icon
Acadia Pharmaceuticals
ACAD
+$56.3M
3
HNGE
Hinge Health
HNGE
+$47.6M
4
INSP icon
Inspire Medical Systems
INSP
+$36.6M
5
CDNA icon
CareDx
CDNA
+$31.1M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$78.1M
2
GH icon
Guardant Health
GH
+$43.6M
3
ADPT icon
Adaptive Biotechnologies
ADPT
+$38.1M
4
NBIX icon
Neurocrine Biosciences
NBIX
+$38M
5
KRYS icon
Krystal Biotech
KRYS
+$31M

Sector Composition

Rank Sector Weight
1 Healthcare 73.36%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CAI
1
Caris Life Sciences
CAI
$4.39B
$221M 6.57%
7,316,142
– –
XENE icon
2
Xenon Pharmaceuticals
XENE
$6.32B
$145M 4.29%
3,605,029
– –
CGON icon
3
CG Oncology
CGON
$6.11B
$132M 3.92%
3,283,317
– –
NBIX icon
4
Neurocrine Biosciences
NBIX
$17.7B
$124M 3.67%
880,282
-280,143
-24% -$38M
KRYS icon
5
Krystal Biotech
KRYS
$9.88B
$91.9M 2.73%
520,401
-207,410
-28% -$31M
NUVL
6
DELISTED
Nuvalent
NUVL
$87.6M 2.6%
1,012,982
-162,894
-14% -$12.9M
SLNO
7
DELISTED
Soleno Therapeutics
SLNO
$86.7M 2.57%
+1,281,989
New +$95M
EWTX icon
8
Edgewise Therapeutics
EWTX
$4.39B
$84.5M 2.51%
5,210,831
– –
INSP icon
9
Inspire Medical Systems
INSP
$1.42B
$65.6M 1.95%
883,747
+361,337
+69% +$36.6M
GKOS icon
10
Glaukos
GKOS
$9.02B
$63.6M 1.89%
780,164
+176,750
+29% +$16.2M
DHR icon
11
Danaher
DHR
$135B
$61.3M 1.82%
309,339
– –
LEGN icon
12
Legend Biotech
LEGN
$4.3B
$59.6M 1.77%
1,826,155
-715,949
-28% -$26.4M
ISRG icon
13
Intuitive Surgical
ISRG
$121B
$58.2M 1.73%
130,227
+40,627
+45% +$19.5M
APGE icon
14
Apogee Therapeutics
APGE
$10.2B
$57.2M 1.7%
1,438,745
-39,767
-3% -$1.52M
ARGX icon
15
argenx
ARGX
$57.4B
$56.1M 1.67%
76,091
-118,400
-61% -$78.1M
TMO icon
16
Thermo Fisher Scientific
TMO
$211B
$55.3M 1.64%
113,933
-21,300
-16% -$9.91M
ALGN icon
17
Align Technology
ALGN
$12B
$51.3M 1.52%
409,691
-87,039
-18% -$13.6M
ACAD icon
18
Acadia Pharmaceuticals
ACAD
$4.25B
$50.8M 1.51%
+2,378,655
New +$56.3M
HNGE
19
Hinge Health
HNGE
$5.75B
$44.7M 1.33%
+910,476
New +$47.6M
SYRE icon
20
Spyre Therapeutics
SYRE
$8.87B
$43.2M 1.28%
2,578,404
– –
TMDX icon
21
Transmedics
TMDX
$2.5B
$39.4M 1.17%
351,248
+96,200
+38% +$11.3M
IRTC icon
22
iRhythm Holdings
IRTC
$3.59B
$38.8M 1.15%
225,845
-74,184
-25% -$11.8M
PEN icon
23
Penumbra
PEN
$12.5B
$35.9M 1.06%
141,528
+11,900
+9% +$3M
DYN icon
24
Dyne Therapeutics
DYN
$4.04B
$34.5M 1.02%
2,730,481
-542,868
-17% -$6.19M
CVS icon
25
CVS Health
CVS
$137B
$33.1M 0.98%
+438,600
New +$30.1M
1
2 3

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Braidwell's Q3 2025 Portfolio in Review

As of Q3 2025, Braidwell held 79 positions worth $3.37B, up 15% from $2.92B the previous quarter. Its ten largest holdings account for 44% of the portfolio.

Braidwell withdrew a net $654M in Q3 2025, closing 6 positions and reducing 18 holdings. Its most notable exit was Guardant Health, an estimated $43.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 73% of assets, up from 72% a quarter earlier.

Against the trend, Braidwell opened a new position in Soleno Therapeutics worth $86.7M.

  • Braidwell's largest Q3 2025 buy was Soleno Therapeutics: 1,281,989 shares worth $86.7M.
  • Braidwell added most to Inspire Medical Systems in Q3 2025, an estimated $36.6M increase.
  • Braidwell's biggest Q3 2025 reduction was argenx, cutting an estimated $78.1M.
  • Braidwell fully exited Guardant Health in Q3 2025, selling an estimated $43.6M.
  • Braidwell's ten largest holdings make up 44% of its $3.37B portfolio in Q3 2025.
  • Braidwell opened 25 new positions and closed 6 in Q3 2025.
  • Braidwell's portfolio value rose 15% quarter-over-quarter to $3.37B.

Based on Braidwell's 13F filing for Q3 2025, filed 14 Nov 2025.