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Adage Capital Partners Portfolio holdings
AUM
$64.8B
1-Year Est. Return
42.7%
This Fund
S&P 500
This Quarter
Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
(+4.7%)
Cap. Flow
+$25.6M
Cap. Flow
% of AUM
0.04%
Top 10 Holdings %
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Merck
MRK
|
+$153M |
| 2 |
Boeing
BA
|
+$150M |
| 3 |
Dominion Energy
D
|
+$129M |
| 4 |
ConocoPhillips
COP
|
+$99.9M |
| 5 |
Revolution Medicines
RVMD
|
+$95.9M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Praxis Precision Medicines
PRAX
|
+$262M |
| 2 |
Chevron
CVX
|
+$229M |
| 3 |
Insmed
INSM
|
+$174M |
| 4 |
Procter & Gamble
PG
|
+$142M |
| 5 |
ETNB
89bio
ETNB
|
+$134M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 29.21% |
| 2 | Healthcare | 15.27% |
| 3 | Financials | 12.11% |
| 4 | Communication Services | 9.26% |
| 5 | Consumer Discretionary | 9.03% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
926
Core & Main
CNM
$8.57B
| – | – |
-404,000
| Closed | -$21.7M |
|
927
CNX Resources
CNX
$5.15B
| – | – |
-1,400,000
| Closed | -$45M |
|
928
Compass
COMP
$9.16B
| – | – |
-400,000
| Closed | -$3.21M |
|
929
Capri Holdings
CPRI
$1.8B
| – | – |
-447,693
| Closed | -$8.92M |
|
930
Crescent Energy
CRGY
$3.72B
| – | – |
-380,564
| Closed | -$3.39M |
|
931
Cytokinetics
CYTK
$10.8B
| – | – |
-38,000
| Closed | -$2.09M |
|
|
DBVT
932
DBV Technologies
DBVT
$852M
| – | – |
-345,934
| Closed | -$3.46M |
|
|
DEC
933
Diversified Energy Company
DEC
$911M
| – | – |
-1,000,000
| Closed | -$14M |
|
934
Dianthus Therapeutics
DNTH
$6.12B
| – | – |
-77,000
| Closed | -$3.03M |
|
935
DigitalOcean
DOCN
$14.8B
| – | – |
-200,000
| Closed | -$6.83M |
|
|
DOCU
936
DocuSign
DOCU
$10.8B
| – | – |
-365,000
| Closed | -$26.3M |
|
937
Duke Energy
DUK
$96.2B
| – | – |
-707,113
| Closed | -$87.5M |
|
938
Encompass Health
EHC
$12.4B
| – | – |
-284,169
| Closed | -$36.1M |
|
939
Enliven Therapeutics
ELVN
$4.33B
| – | – |
-73,000
| Closed | -$1.49M |
|
940
Eastman Chemical
EMN
$8.55B
| – | – |
-104,543
| Closed | -$6.59M |
|
941
enGene Therapeutics
ENGN
$121M
| – | – |
-1,000,000
| Closed | -$6.83M |
|
942
Epsilon Energy
EPSN
$168M
| – | – |
-101,835
| Closed | -$513K |
|
943
Essex Property Trust
ESS
$18.4B
| – | – |
-43,600
| Closed | -$11.7M |
|
|
ETNB
944
DELISTED
89bio
ETNB
| – | – |
-9,097,587
| Closed | -$134M |
|
945
Evercore
EVR
$12.2B
| – | – |
-13,000
| Closed | -$4.39M |
|
|
PLGO
946
Pelagos Insurance Capital
PLGO
$2.19B
| – | – |
-900,000
| Closed | -$16.3M |
|
|
FITB
947
Fifth Third Bancorp
FITB
$51.8B
| – | – |
-497,597
| Closed | -$22.2M |
|
948
Franco-Nevada
FNV
$43.9B
| – | – |
-100,000
| Closed | -$22.3M |
|
|
CBIO
949
Crescent Biopharma
CBIO
$604M
| – | – |
-200,005
| Closed | -$2.38M |
|
950
Gossamer Bio
GOSS
$86.3M
| – | – |
-726,800
| Closed | -$1.91M |
|
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Adage Capital Partners's Q4 2025 Portfolio in Review
As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.
Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.
By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.
- Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
- Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
- Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
- Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
- Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
- Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
- Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.
Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.