Adage Capital Partners Portfolio holdings

AUM $54B

AUM

$54B

AUM Growth

-$3.22B (-6%)

Cap. Flow

+$807M

Cap. Flow % of AUM

1.5%

Top 10 Holdings %Top 10 Hldgs %

28.72%

Holding

985

New

115

Increased

314

Reduced

359

Closed

149

Top Buys

1	Hubbell HUBB	$208M
2	Norfolk Southern NSC	$145M
3	Insmed INSM	$137M
4	Vertex Pharmaceuticals VRTX	$136M
5	Soleno Therapeutics SLNO	$116M

Top Sells

1	Bristol-Myers Squibb BMY	$355M
2	Royalty Pharma RPRX	$334M
3	McDonald's MCD	$198M
4	Union Pacific UNP	$188M
5	Hess HES	$182M

Sector Composition

1	Technology	26.31%
2	Healthcare	14.97%
3	Financials	12.6%
4	Consumer Discretionary	9.55%
5	Industrials	8.67%

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
926	926 Meritage Homes MTH $5.3B	$0	0%	0 -65,000	Closed	–
927	927 Norwegian Cruise Line NCLH $10.1B	$0	0%	0 -410,800	Closed	–
928	928 Annaly Capital Management NLY $11.9B	$0	0%	0 -900,000	Closed	–
929	929 NET Power Inc. Redeemable warrants, each whole warrant exercisable for one share of Class A Common Stock at an exercise price of $11.50 NPWR.WS $73.2M	$0	0%	0 -20,000	Closed	–
930	930 NovoCure NVCR $1.96B	$0	0%	0 -200,000	Closed	–
931	931 Northwest Natural Holdings NWN $1.67B	$0	0%	0 -241,242	Closed	–
932	932 Olema Pharmaceuticals OLMA $318M	$0	0%	0 -365,198	Closed	–
933	933 Omnicom Group OMC $14.2B	$0	0%	0 -31,410	Closed	–
934	934 Oric Pharmaceuticals ORIC $946M	$0	0%	0 -500,000	Closed	–
935	935 Public Service Enterprise Group PEG $41.2B	$0	0%	0 -640,484	Closed	–
936	936 Pinterest PINS $24B	$0	0%	0 -250,000	Closed	–
937	937 Plumas Bancorp PLBC $316M	$0	0%	0 -4,693	Closed	–
938	938 Pliant Therapeutics PLRX $86.6M	$0	0%	0 -649,660	Closed	–
939	939 Permian Resources PR $9.92B	$0	0%	0 -45,000	Closed	–
940	940 Arcus Biosciences RCUS $988M	$0	0%	0 -443,000	Closed	–
941	941 Reinsurance Group of America RGA $12.9B	$0	0%	0 -100,000	Closed	–
942	942 Regenxbio RGNX $437M	$0	0%	0 -500,000	Closed	–
943	RGLS 943 DELISTED Regulus Therapeutics RGLS	$0	0%	0 -2,000,000	Closed	–
944	944 Ralph Lauren RL $17.4B	$0	0%	0 -22,126	Closed	–
945	945 Relay Therapeutics RLAY $617M	$0	0%	0 -1,400,000	Closed	–
946	946 Roper Technologies ROP $58.9B	$0	0%	0 -116,813	Closed	–
947	947 Rezolute RZLT $457M	$0	0%	0 -2,525,883	Closed	–
948	948 Selective Insurance SIGI $5.24B	$0	0%	0 -10,000	Closed	–
949	949 Amplify Junior Silver Miners ETF SILJ $1.52B	$0	0%	0 -75,000	Closed	–
950	950 SL Green Realty SLG $4.54B	$0	0%	0 -35,000	Closed	–