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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
JHG
801
DELISTED
Janus Henderson
JHG
$3.33M 0.01%
+70,000
New +$3.1M
NWS icon
802
News Corp Class B
NWS
$18.3B
$3.3M 0.01%
111,434
-1,800
-2% -$53.7K
CAH icon
803
Cardinal Health
CAH
$55.7B
$3.22M ﹤0.01%
+15,649
New +$2.95M
NXDR
804
Nextdoor Holdings
NXDR
$983M
$3.15M ﹤0.01%
1,500,000
+500,001
+50% +$980K
HRMY icon
805
Harmony Biosciences
HRMY
$2.26B
$3.14M ﹤0.01%
+84,000
New +$2.76M
CNS icon
806
Cohen & Steers
CNS
$4.34B
$3.14M ﹤0.01%
+50,000
New +$3.25M
KPTI icon
807
Karyopharm Therapeutics
KPTI
$44.2M
$3.1M ﹤0.01%
421,322
– –
JBHT icon
808
JB Hunt Transport Services
JBHT
$25.1B
$3.03M ﹤0.01%
15,607
-28,993
-65% -$4.98M
BBWI icon
809
Bath & Body Works
BBWI
$4.06B
$3.01M ﹤0.01%
150,000
+50,000
+50% +$1.1M
DXPE icon
810
DXP Enterprises
DXPE
$3.07B
$2.96M ﹤0.01%
+27,000
New +$2.94M
CON
811
Concentra Group Holdings
CON
$3.91B
$2.94M ﹤0.01%
+149,421
New +$2.99M
HIW icon
812
Highwoods Properties
HIW
$3.47B
$2.83M ﹤0.01%
109,454
-267,193
-71% -$7.54M
IR icon
813
Ingersoll Rand
IR
$34.2B
$2.74M ﹤0.01%
34,592
-582,880
-94% -$46M
SNDR icon
814
Schneider National
SNDR
$6.17B
$2.72M ﹤0.01%
102,516
-133,648
-57% -$3.15M
KTTA icon
815
Pasithea Therapeutics
KTTA
$14.8M
$2.71M ﹤0.01%
+2,100,000
New +$1.85M
ALHC icon
816
Alignment Healthcare
ALHC
$2.78B
$2.68M ﹤0.01%
135,771
-148,100
-52% -$2.66M
ACHR icon
817
Archer Aviation
ACHR
$3.99B
$2.63M ﹤0.01%
350,000
-900,000
-72% -$8.47M
PPL
818
PPL Corp
PPL
$26B
$2.63M ﹤0.01%
75,018
-598,182
-89% -$21.6M
TWO
819
Two Harbors Investment
TWO
$1.26B
$2.63M ﹤0.01%
+250,000
New +$2.5M
CEPV
820
Cantor Equity Partners V
CEPV
$331M
$2.56M ﹤0.01%
+250,000
New +$2.56M
CHRW icon
821
C.H. Robinson
CHRW
$17.1B
$2.54M ﹤0.01%
15,814
-41,409
-72% -$6.12M
ZVRA icon
822
Zevra Therapeutics
ZVRA
$702M
$2.46M ﹤0.01%
275,000
-1,950,000
-88% -$18.4M
STRO icon
823
Sutro Biopharma
STRO
$400M
$2.31M ﹤0.01%
200,000
– –
ACET icon
824
Adicet Bio
ACET
$74.1M
$2.31M ﹤0.01%
+274,375
New +$3.03M
SEI
825
Solaris Energy Infrastructure
SEI
$3.49B
$2.3M ﹤0.01%
+50,000
New +$2.42M
31 32
33
34 35

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.