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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
EVTL icon
751
Vertical Aerospace
EVTL
$160M
$5.38M 0.01%
1,010,101
+610,101
+153% +$3.09M
DYNC
752
Dynamix Corp
DYNC
$240M
$5.34M 0.01%
+519,086
New +$5.38M
GEHC icon
753
GE HealthCare
GEHC
$31.8B
$5.32M 0.01%
64,867
-46,109
-42% -$3.59M
LNT icon
754
Alliant Energy
LNT
$18B
$5.27M 0.01%
81,108
-152,800
-65% -$10.2M
OLMA icon
755
Olema Pharmaceuticals
OLMA
$1.03B
$5.25M 0.01%
+210,000
New +$3.74M
ESRT icon
756
Empire State Realty Trust
ESRT
$843M
$5.12M 0.01%
785,191
-114,809
-13% -$819K
NVGS icon
757
Navigator Holdings
NVGS
$1.29B
$5.05M 0.01%
291,578
+100,000
+52% +$1.67M
PHR icon
758
Phreesia
PHR
$706M
$5.04M 0.01%
298,042
+221,842
+291% +$4.58M
MESHU
759
Meshflow Acquisition Corp Units
MESHU
$5M 0.01%
+500,000
New +$5M
CORZ icon
760
Core Scientific
CORZ
$6.76B
$5M 0.01%
343,135
-975,000
-74% -$17M
CBOE icon
761
Cboe Global Markets
CBOE
$30.2B
$4.96M 0.01%
+19,747
New +$4.91M
LB
762
LandBridge Co
LB
$2.24B
$4.9M 0.01%
+100,000
New +$5.82M
PFG icon
763
Principal Financial Group
PFG
$24.7B
$4.9M 0.01%
+55,500
New +$4.68M
GPGI
764
GPGI Inc
GPGI
$4.34B
$4.82M 0.01%
+250,000
New +$4.99M
OSBC icon
765
Old Second Bancorp
OSBC
$1.31B
$4.74M 0.01%
+243,192
New +$4.54M
ARTNA icon
766
Artesian Resources
ARTNA
$355M
$4.74M 0.01%
150,000
– –
LYV icon
767
Live Nation Entertainment
LYV
$42.3B
$4.72M 0.01%
33,100
-1,000
-3% -$144K
CENX icon
768
Century Aluminum
CENX
$4.55B
$4.7M 0.01%
120,000
-175,000
-59% -$5.47M
MOD icon
769
Modine Manufacturing
MOD
$10.2B
$4.67M 0.01%
35,000
-38,000
-52% -$5.66M
RAPP
770
Rapport Therapeutics
RAPP
$2.22B
$4.55M 0.01%
150,000
-300,000
-67% -$8.3M
BLRKU
771
Bluerock Acquisition Corp Unit
BLRKU
$153M
$4.5M 0.01%
+450,000
New +$4.5M
ORIC icon
772
Oric Pharmaceuticals
ORIC
$1.34B
$4.49M 0.01%
549,000
+101,634
+23% +$1.17M
INO icon
773
Inovio Pharmaceuticals
INO
$69.6M
$4.44M 0.01%
2,553,571
-875,000
-26% -$1.93M
NDSN icon
774
Nordson
NDSN
$17.2B
$4.38M 0.01%
18,200
-30,700
-63% -$7.21M
ATRC icon
775
AtriCure
ATRC
$2.01B
$4.36M 0.01%
110,210
-64,790
-37% -$2.38M
29 30
31
32 33

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.