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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HBT icon
726
HBT Financial
HBT
$1.32B
$6.66M 0.01%
257,579
+87,085
+51% +$2.15M
AEVA
727
Aeva Technologies
AEVA
$1.73B
$6.64M 0.01%
500,000
+150,000
+43% +$2.14M
FRMI
728
Fermi Inc
FRMI
$3.95B
$6.56M 0.01%
+820,000
New +$16M
SYF icon
729
Synchrony
SYF
$25.6B
$6.54M 0.01%
78,361
-169,326
-68% -$12.9M
RARE icon
730
Ultragenyx Pharmaceutical
RARE
$2.54B
$6.44M 0.01%
280,000
-150,000
-35% -$4.93M
BAH icon
731
Booz Allen Hamilton
BAH
$8.89B
$6.32M 0.01%
+74,882
New +$6.7M
HRL icon
732
Hormel Foods
HRL
$13.8B
$6.24M 0.01%
263,146
-2,200
-0.8% -$51.3K
SUNC
733
SunocoCorp LLC
SUNC
$3.76B
$6.24M 0.01%
+126,532
New +$6.37M
AESI icon
734
Atlas Energy Solutions
AESI
$1.38B
$6.13M 0.01%
650,912
-230,000
-26% -$2.33M
EPAM icon
735
EPAM Systems
EPAM
$4.86B
$6.13M 0.01%
29,900
+9,200
+44% +$1.64M
TXT icon
736
Textron
TXT
$15.1B
$6.03M 0.01%
69,126
-149,491
-68% -$12.5M
BORR
737
Borr Drilling
BORR
$1.2B
$6M 0.01%
+1,487,900
New +$4.93M
ITHAU
738
ITHAX Acquisition Corp III Units
ITHAU
$5.99M 0.01%
+600,000
New +$5.98M
AVBH
739
Avidbank Holdings
AVBH
$358M
$5.85M 0.01%
220,315
+30,000
+16% +$778K
AVAH icon
740
Aveanna Healthcare
AVAH
$2.03B
$5.78M 0.01%
+706,874
New +$6.38M
HELP
741
Cybin Inc
HELP
$688M
$5.73M 0.01%
+700,000
New +$4.51M
OVID icon
742
Ovid Therapeutics
OVID
$495M
$5.69M 0.01%
3,492,000
+2,142,000
+159% +$3.3M
MIST icon
743
Milestone Pharmaceuticals
MIST
$147M
$5.68M 0.01%
2,810,037
-4,165,963
-60% -$8.97M
CSTM icon
744
Constellium
CSTM
$3.88B
$5.66M 0.01%
+300,000
New +$4.98M
CLDT
745
Chatham Lodging
CLDT
$607M
$5.62M 0.01%
824,722
-10,459
-1% -$69.4K
INVH icon
746
Invitation Homes
INVH
$18B
$5.6M 0.01%
201,535
+115,800
+135% +$3.23M
CAG icon
747
Conagra Brands
CAG
$7.11B
$5.59M 0.01%
322,845
+53,700
+20% +$954K
TARA icon
748
Protara Therapeutics
TARA
$230M
$5.56M 0.01%
+1,043,478
New +$5.8M
JANX icon
749
Janux Therapeutics
JANX
$982M
$5.52M 0.01%
400,000
-2,375,000
-86% -$55.9M
ASMB icon
750
Assembly Biosciences
ASMB
$524M
$5.48M 0.01%
+161,000
New +$5.19M
28 29
30
31 32

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.