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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
EQ icon
701
Equillium
EQ
$134M
$8.26M 0.01%
5,329,416
– –
SNOW icon
702
Snowflake
SNOW
$110B
$8.23M 0.01%
+37,500
New +$9.15M
HLX icon
703
Helix Energy Solutions
HLX
$1.45B
$8.15M 0.01%
1,300,000
-350,000
-21% -$2.33M
SLDB icon
704
Solid Biosciences
SLDB
$857M
$7.9M 0.01%
1,400,000
-2,600,000
-65% -$14.1M
BRX icon
705
Brixmor Property Group
BRX
$9.25B
$7.87M 0.01%
+300,000
New +$7.92M
CHWY icon
706
Chewy
CHWY
$9.59B
$7.87M 0.01%
+238,000
New +$8.26M
IMMX icon
707
Immix Biopharma
IMMX
$716M
$7.84M 0.01%
+1,500,000
New +$6.17M
SN icon
708
SharkNinja
SN
$25.5B
$7.83M 0.01%
+70,000
New +$6.9M
XHR
709
Xenia Hotels & Resorts
XHR
$1.82B
$7.78M 0.01%
550,000
+20,000
+4% +$273K
PENN icon
710
PENN Entertainment
PENN
$2.69B
$7.78M 0.01%
527,197
+75,000
+17% +$1.17M
BRKR icon
711
Bruker
BRKR
$7.8B
$7.77M 0.01%
164,883
-35,117
-18% -$1.48M
ALGN icon
712
Align Technology
ALGN
$12.1B
$7.68M 0.01%
49,200
-12,200
-20% -$1.75M
TSM icon
713
TSMC
TSM
$2.17T
$7.6M 0.01%
25,000
-125,000
-83% -$36.7M
QNCX icon
714
Quince Therapeutics
QNCX
$28.9M
$7.54M 0.01%
+11,250
New +$5.66M
FAST icon
715
Fastenal
FAST
$58.3B
$7.49M 0.01%
186,592
-413,316
-69% -$17.4M
TSHA icon
716
Taysha Gene Therapies
TSHA
$1.82B
$7.3M 0.01%
1,328,000
-2,000,000
-60% -$9.71M
OLN icon
717
Olin
OLN
$2.14B
$7.29M 0.01%
350,000
+250,000
+250% +$5.39M
GNRC icon
718
Generac Holdings
GNRC
$12.5B
$7.22M 0.01%
52,958
+34,500
+187% +$5.57M
TAP icon
719
Molson Coors Class B
TAP
$7.95B
$7.13M 0.01%
152,836
-1,400
-0.9% -$64.6K
RHP icon
720
Ryman Hospitality Properties
RHP
$7.84B
$7.1M 0.01%
75,000
+11,060
+17% +$1.02M
PAYC icon
721
Paycom
PAYC
$10.1B
$7.03M 0.01%
44,100
-1,500
-3% -$266K
FDS icon
722
Factset
FDS
$9.77B
$6.91M 0.01%
23,800
-2,600
-10% -$730K
MOS icon
723
The Mosaic Company
MOS
$7.46B
$6.9M 0.01%
286,520
-517,400
-64% -$13.9M
AN icon
724
AutoNation
AN
$6.99B
$6.81M 0.01%
33,000
-67,000
-67% -$13.9M
MGM icon
725
MGM Resorts International
MGM
$11.4B
$6.76M 0.01%
185,200
-600
-0.3% -$20.4K
27 28
29
30 31

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.