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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+879.75%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TSN icon
576
Tyson Foods
TSN
$20.6B
$15M 0.02%
255,555
-4,600
-2% -$253K
EGP icon
577
EastGroup Properties
EGP
$10.8B
$14.9M 0.02%
83,604
+22,958
+38% +$4.08M
EL icon
578
Estee Lauder
EL
$30.9B
$14.9M 0.02%
141,984
+68,800
+94% +$6.68M
COO icon
579
Cooper Companies
COO
$14.3B
$14.7M 0.02%
179,460
-280,200
-61% -$21M
PNW icon
580
Pinnacle West Capital
PNW
$12.2B
$14.6M 0.02%
164,986
+56,303
+52% +$5.04M
ONB icon
581
Old National Bancorp
ONB
$10.2B
$14.6M 0.02%
655,000
+200,000
+44% +$4.31M
WTFC icon
582
Wintrust Financial
WTFC
$10.7B
$14.6M 0.02%
104,200
-5,000
-5% -$665K
MMSI icon
583
Merit Medical Systems
MMSI
$5.24B
$14.5M 0.02%
165,000
-11,162
-6% -$950K
HRTX icon
584
Heron Therapeutics
HRTX
$94.5M
$14.5M 0.02%
11,185,325
+946,100
+9% +$1.17M
ZURA icon
585
Zura Bio
ZURA
$542M
$14.4M 0.02%
2,750,000
-295,444
-10% -$1.17M
J icon
586
Jacobs Solutions
J
$16.9B
$14.3M 0.02%
107,927
-900
-0.8% -$132K
LPLA icon
587
LPL Financial
LPLA
$28.3B
$14.3M 0.02%
+40,000
New +$14.1M
KRP icon
588
Kimbell Royalty Partners
KRP
$1.43B
$14.2M 0.02%
1,210,948
+294,482
+32% +$3.77M
BIOA
589
BioAge Labs
BIOA
$501M
$13.9M 0.02%
+1,050,000
New +$9.31M
NVS icon
590
Novartis
NVS
$293B
$13.8M 0.02%
100,188
-110,000
-52% -$14.4M
MDGL icon
591
Madrigal Pharmaceuticals
MDGL
$11.8B
$13.5M 0.02%
23,226
-65,274
-74% -$33.3M
RPM icon
592
RPM International
RPM
$14.8B
$13.5M 0.02%
130,000
-100,000
-43% -$10.8M
NGD
593
DELISTED
New Gold Inc
NGD
$13.5M 0.02%
+1,550,000
New +$11.7M
LATA
594
Galata Acquisition Corp II
LATA
$13.4M 0.02%
+1,350,000
New +$13.5M
SYY icon
595
Sysco
SYY
$40.4B
$13.4M 0.02%
+182,324
New +$13.9M
TWLVU
596
Twelve Seas Investment Company III Units
TWLVU
$13.4M 0.02%
+1,350,000
New +$13.5M
Q
597
Qnity Electronics Inc
Q
$27.9B
$13.4M 0.02%
+164,100
New +$13.9M
DD icon
598
DuPont de Nemours
DD
$19.5B
$13.4M 0.02%
111,067
-156,773
-59% -$17.6M
DYOR
599
Insight Digital Partners II
DYOR
$13.4M 0.02%
+1,350,000
New +$13.4M
CAMP icon
600
CAMP4 Therapeutics
CAMP
$282M
$13.4M 0.02%
2,181,679
+220,895
+11% +$940K
22 23
24
25 26

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.