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Adage Capital Partners

Adage Capital Partners Portfolio holdings

AUM $64.8B
1-Year Est. Return 42.7%
This Fund
S&P 500
This Quarter Est. Return
+9.6%
1 Year Est. Return
+42.7%
3 Year Est. Return
+139.29%
5 Year Est. Return
+204.38%
10 Year Est. Return
+829.83%
AUM
$66.1B
AUM Growth
+$2.94B
Cap. Flow
+$25.6M
Cap. Flow %
0.04%
Top 10 Hldgs %
31.48%
Holding
1,052
New
179
Increased
308
Reduced
377
Closed
147

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$153M
2
BA icon
Boeing
BA
+$150M
3
D icon
Dominion Energy
D
+$129M
4
COP icon
ConocoPhillips
COP
+$99.9M
5
RVMD icon
Revolution Medicines
RVMD
+$95.9M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$262M
2
CVX icon
Chevron
CVX
+$229M
3
INSM icon
Insmed
INSM
+$174M
4
PG icon
Procter & Gamble
PG
+$142M
5
ETNB
89bio
ETNB
+$134M

Sector Composition

Rank Sector Weight
1 Technology 29.21%
2 Healthcare 15.27%
3 Financials 12.11%
4 Communication Services 9.26%
5 Consumer Discretionary 9.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
COST icon
26
Costco
COST
$422B
$336M 0.51%
389,577
-700
-0.2% -$634K
BA icon
27
Boeing
BA
$171B
$333M 0.5%
1,534,944
+729,708
+91% +$150M
TMO icon
28
Thermo Fisher Scientific
TMO
$213B
$327M 0.49%
564,168
+25,288
+5% +$14.3M
XOM icon
29
ExxonMobil
XOM
$644B
$320M 0.48%
2,661,722
+609,770
+30% +$70.7M
MU icon
30
Micron Technology
MU
$930B
$317M 0.48%
1,110,803
-66,800
-6% -$15.3M
DOV icon
31
Dover
DOV
$27.6B
$304M 0.46%
1,556,098
-541,904
-26% -$98.7M
CSCO icon
32
Cisco
CSCO
$457B
$301M 0.46%
3,907,721
-193,300
-5% -$14.3M
AMD icon
33
Advanced Micro Devices
AMD
$776B
$297M 0.45%
1,384,794
-1,800
-0.1% -$404K
UNH icon
34
UnitedHealth
UNH
$376B
$285M 0.43%
864,352
+143,101
+20% +$48.5M
PRAX icon
35
Praxis Precision Medicines
PRAX
$8.58B
$285M 0.43%
965,313
-1,408,772
-59% -$262M
MRK icon
36
Merck
MRK
$322B
$283M 0.43%
2,687,850
+1,634,216
+155% +$153M
CNTA
37
DELISTED
Centessa Pharmaceuticals
CNTA
$282M 0.43%
11,281,741
+1,246,741
+12% +$31.6M
CRM icon
38
Salesforce
CRM
$151B
$281M 0.42%
1,059,439
-34,900
-3% -$8.67M
GE icon
39
GE Aerospace
GE
$374B
$273M 0.41%
886,363
+68,633
+8% +$20.7M
CVX icon
40
Chevron
CVX
$392B
$271M 0.41%
1,780,166
-1,504,675
-46% -$229M
IBM icon
41
IBM
IBM
$211B
$262M 0.4%
883,890
-33,252
-4% -$9.96M
WFC icon
42
Wells Fargo
WFC
$261B
$251M 0.38%
2,697,196
-93,700
-3% -$8.13M
KO icon
43
Coca-Cola
KO
$377B
$239M 0.36%
3,425,082
+244,900
+8% +$17.1M
ROIV icon
44
Roivant Sciences
ROIV
$24.5B
$232M 0.35%
10,677,894
+3,445,511
+48% +$68M
NSC icon
45
Norfolk Southern
NSC
$75.4B
$230M 0.35%
798,093
+275,236
+53% +$79.6M
PM icon
46
Philip Morris
PM
$297B
$226M 0.34%
1,406,954
-8,500
-0.6% -$1.32M
TERN
47
DELISTED
Terns Pharmaceuticals
TERN
$224M 0.34%
5,550,000
+1,611,000
+41% +$37.2M
DIS icon
48
Walt Disney
DIS
$167B
$223M 0.34%
1,961,725
+26,800
+1% +$2.95M
LRCX icon
49
Lam Research
LRCX
$367B
$221M 0.33%
1,291,620
-105,700
-8% -$16.4M
VNOM icon
50
Viper Energy
VNOM
$8.71B
$221M 0.33%
5,711,539
+1,024,838
+22% +$38.8M
1
2
3 4 5

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Adage Capital Partners's Q4 2025 Portfolio in Review

As of Q4 2025, Adage Capital Partners held 1,052 positions worth $66.1B, up 4.7% from $63.1B the previous quarter. Its ten largest holdings account for 31% of the portfolio.

Adage Capital Partners's Q4 2025 filing shows 179 new, 308 increased, 377 reduced and 147 closed positions. Its largest new stake was Dominion Energy: 2,141,911 shares worth $125M. The largest sale was Praxis Precision Medicines, an estimated $262M.

By sector, the portfolio is most concentrated in Technology at 29% of assets, down from 30% a quarter earlier, followed by Healthcare and Financials.

  • Adage Capital Partners's largest Q4 2025 buy was Dominion Energy: 2,141,911 shares worth $125M.
  • Adage Capital Partners added most to Merck in Q4 2025, an estimated $153M increase.
  • Adage Capital Partners's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $262M.
  • Adage Capital Partners fully exited 89bio in Q4 2025, selling an estimated $134M.
  • Adage Capital Partners's ten largest holdings make up 31% of its $66.1B portfolio in Q4 2025.
  • Adage Capital Partners opened 179 new positions and closed 147 in Q4 2025.
  • Adage Capital Partners's portfolio value rose 4.7% quarter-over-quarter to $66.1B.

Based on Adage Capital Partners's 13F filing for Q4 2025, filed 17 Feb 2026.