|
26
|
Loomis, Sayles & Company
Boston,
Massachusetts
|
$736M
|
-$344K
|
3
|
1.01%
|
Reduced
|
|
|
27
|
ARK Investment Management
St. Petersburg,
Florida
|
$712M
|
-$6.66M
|
4
|
6.31%
|
Reduced
|
|
|
28
|
RA Capital Management
Boston,
Massachusetts
|
$711M
|
+$124M
|
11
|
9.4%
|
Increased
|
|
|
29
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$700M
|
-$235M
|
10
|
0.44%
|
Reduced
|
|
|
30
|
Viking Global Investors
Stamford,
Connecticut
|
$698M
|
$0
|
2
|
2.68%
|
Maintained
|
|
|
31
|
Nomura Holdings
Tokyo,
Japan
|
$637M
|
-$11.7M
|
6
|
1.22%
|
Reduced
|
|
|
32
|
|
$630M
|
+$23.8M
|
18
|
0.09%
|
Increased
|
|
|
33
|
Citadel Advisors
Miami,
Florida
|
$626M
|
+$4.66M
|
64
|
0.13%
|
Increased
|
|
|
34
|
EcoR1 Capital
San Francisco,
California
|
$625M
|
-$47.8M
|
13
|
19.11%
|
Reduced
|
|
|
35
|
Millennium Management
New York
|
$610M
|
+$110M
|
64
|
0.28%
|
Increased
|
|
|
36
|
Charles Schwab
San Francisco,
California
|
$580M
|
+$44.4M
|
57
|
0.11%
|
Increased
|
|
|
37
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$557M
|
+$98M
|
51
|
0.25%
|
Increased
|
|
|
38
|
Perceptive Advisors
New York
|
$538M
|
-$79.7M
|
13
|
12.96%
|
Reduced
|
|
|
39
|
|
$485M
|
+$16.3M
|
10
|
37.02%
|
Increased
|
|
|
40
|
Paradigm Biocapital Advisors
New York
|
$485M
|
-$68.4M
|
6
|
18.55%
|
Reduced
|
|
|
41
|
Capital World Investors
Los Angeles,
California
|
$483M
|
-$429M
|
4
|
0.08%
|
Reduced
|
|
|
42
|
Adage Capital Partners
Boston,
Massachusetts
|
$470M
|
+$39M
|
24
|
0.87%
|
Increased
|
|
|
43
|
Barclays
London,
United Kingdom
|
$431M
|
+$9.69M
|
65
|
0.13%
|
Increased
|
|
|
44
|
Principal Financial Group
Des Moines,
Iowa
|
$425M
|
+$21.8M
|
30
|
0.25%
|
Increased
|
|
|
45
|
ClearBridge Investments
New York
|
$417M
|
-$23.7M
|
4
|
0.34%
|
Reduced
|
|
|
46
|
Renaissance Technologies
New York
|
$410M
|
-$40.4M
|
57
|
0.7%
|
Reduced
|
|
|
47
|
UBS Group
Zurich,
Switzerland
|
$407M
|
-$19.6M
|
88
|
0.1%
|
Reduced
|
|
|
48
|
Balyasny Asset Management
Chicago,
Illinois
|
$397M
|
+$209M
|
21
|
0.69%
|
Increased
|
|
|
49
|
Redmile Group
San Francisco,
California
|
$397M
|
-$84.3M
|
11
|
24%
|
Reduced
|
|
|
50
|
Wells Fargo
San Francisco,
California
|
$396M
|
+$12.5M
|
75
|
0.1%
|
Increased
|
|