Zura Bio
ZURA
75 hedge funds and large institutions have $235M invested in Zura Bio in 2025 Q4 according to their latest regulatory filings, with 22 funds opening new positions, 25 increasing their positions, 19 reducing their positions, and 14 closing their positions.
57% more first-time investments, than exits
New positions opened: 22 | Existing positions closed: 14
32% more repeat investments, than reductions
Existing positions increased: 25 | Existing positions reduced: 19
31% more capital invested
Capital invested by funds: $179M → $235M (+$55.9M)
9% more funds holding
Funds holding: 69 → 75 (+6)
5.35% more ownership
Funds ownership: 63.67% → 69.01% (+5.3%)
0% more funds holding in top 10
Funds holding in top 10: 2 → 2 (0)
98% less call options, than puts
Call options by funds: $96K | Put options by funds: $4.24M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$5.14M |
| 2 |
Morgan Stanley
New York
|
+$5.14M |
| 3 |
VA
VR Adviser
New York
|
+$2.82M |
| 4 |
B
Braidwell
Stamford,
Connecticut
|
+$2.8M |
| 5 |
Marshall Wace
London,
United Kingdom
|
+$2.41M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
IC
Ikarian Capital
Dallas,
Texas
|
-$5.26M |
| 2 |
SCM
Silverarc Capital Management
Boston,
Massachusetts
|
-$3.12M |
| 3 |
BFM
Boothbay Fund Management
New York
|
-$2.22M |
| 4 |
Ameriprise
Minneapolis,
Minnesota
|
-$2.17M |
| 5 |
Point72 Asset Management
Stamford,
Connecticut
|
-$1.98M |
ZURA Hedge Fund Activity: Q4 2025 in Review
75 of the 8,274 institutional investors tracked by Wall St. Rank reported a position in Zura Bio (ZURA) for Q4 2025, worth a combined $235M — up 31% from $179M a quarter earlier.
Buyers outnumbered sellers: 22 funds opened new ZURA positions and 14 closed out — a net gain of 8 holders — while 25 added to existing stakes and 19 trimmed.
The largest buyer was Siren LLC, opening a new position worth an estimated $5.14M. The largest seller was Ikarian Capital, cutting an estimated $5.26M.
- 75 institutional investors held Zura Bio (ZURA) as of Q4 2025, up from 69 in Q3 2025.
- Funds reported $235M of Zura Bio stock for Q4 2025, up 31% quarter-over-quarter.
- 22 funds opened new Zura Bio positions in Q4 2025 and 14 closed out, a net change of +8 holders.
- The largest Zura Bio buyer in Q4 2025 was Siren LLC, an estimated $5.14M added.
- The largest Zura Bio seller in Q4 2025 was Ikarian Capital, an estimated $5.26M sold.
Based on aggregated 13F filings for Q4 2025.