Xoma
XOMA
XOMA was delisted on the 13th of July, 2026.
74 hedge funds and large institutions have $230M invested in Xoma in 2025 Q4 according to their latest regulatory filings, with 9 funds opening new positions, 30 increasing their positions, 17 reducing their positions, and 9 closing their positions.
600% more call options, than puts
Call options by funds: $21K | Put options by funds: $3K
76% more repeat investments, than reductions
Existing positions increased: 30 | Existing positions reduced: 17
0.8% more ownership
Funds ownership: 68.92% → 69.72% (+0.8%)
0% more funds holding
Funds holding: 74 → 74 (0)
0% more first-time investments, than exits
New positions opened: 9 | Existing positions closed: 9
28% less capital invested
Capital invested by funds: $320M → $230M (-$90.3M)
67% less funds holding in top 10
Funds holding in top 10: 3 → 1 (-2)
Top Buyers
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
+$2.82M |
| 2 |
Morgan Stanley
New York
|
+$2.18M |
| 3 |
WP
Woodline Partners
San Francisco,
California
|
+$1.71M |
| 4 |
OM
Opaleye Management
Boston,
Massachusetts
|
+$1.21M |
| 5 |
Vanguard Group
Malvern,
Pennsylvania
|
+$1.08M |
Top Sellers
| 1 |
TA
TLS Advisors
Miami,
Florida
|
-$2.15M |
| 2 |
Jane Street
New York
|
-$1.05M |
| 3 |
State of Wisconsin Investment Board
Madison,
Wisconsin
|
-$523K |
| 4 |
Citadel Advisors
Miami,
Florida
|
-$292K |
| 5 |
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
-$269K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
76
State of Wisconsin Investment Board
Madison,
Wisconsin
| – | -$523K | -13,571 | Closed |
|
|
77
Citadel Advisors
Miami,
Florida
| – | -$292K | -7,581 | Closed |
|
78
Macquarie Group
Sydney, NSW 2000,
Australia
| – | -$221K | -6,932 | Closed |
|
79
Man Group
London,
United Kingdom
| – | -$247K | -6,397 | Closed |
|
|
WANY
80
Wealthspire Advisors (New York)
New York
| – | -$3.85K | -100 | Closed |
|
|
QCG
81
Quadrant Capital Group
Cincinnati,
Ohio
| – | -$1.35K | -35 | Closed |
|
|
TIM
82
Tortoise Investment Management
White Plains,
New York
| – | -$77 | -2 | Closed |
|
|
ASN
83
Advisory Services Network
Atlanta,
Georgia
| – | -$39 | -1 | Closed |
|
XOMA Hedge Fund Activity: Q4 2025 in Review
74 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Xoma (XOMA) for Q4 2025, worth a combined $230M — down 28% from $320M a quarter earlier.
Fund positioning in XOMA was balanced in Q4 2025: 9 funds opened new positions, 9 closed out, 30 added to existing stakes and 17 trimmed.
The largest buyer was Fidelity Investments, adding an estimated $2.82M. The largest seller was TLS Advisors, cutting an estimated $2.15M.
- 74 institutional investors held Xoma (XOMA) as of Q4 2025, unchanged from Q3 2025.
- Funds reported $230M of Xoma stock for Q4 2025, down 28% quarter-over-quarter.
- 9 funds opened new Xoma positions in Q4 2025 and 9 closed out, a net change of 0 holders.
- The largest Xoma buyer in Q4 2025 was Fidelity Investments, an estimated $2.82M added.
- The largest Xoma seller in Q4 2025 was TLS Advisors, an estimated $2.15M sold.
Based on aggregated 13F filings for Q4 2025.