Opaleye Management’s Xoma XOMA Stock Holding History

Opaleye Management’s Portfolio XOMA Stock Details XOMA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$9.41M	Buy	300,000 +7,410	+3%	+$198K	1.24%	23
2025 Q4	$7.78M	Buy	292,590 +37,503	+15%	+$1.21M	1.03%	24
2025 Q3	$9.83M	Hold	255,087	–	–	1.39%	17
2025 Q2	$6.43M	Buy	255,087 +2,044	+0.8%	+$49K	1.3%	16
2025 Q1	$5.04M	Buy	253,043 +3,043	+1%	+$73.3K	1.12%	17
2024 Q4	$6.57M	Hold	250,000	–	–	1.15%	19
2024 Q3	$6.62M	Hold	250,000	–	–	1.1%	21
2024 Q2	$5.92M	Hold	250,000	–	–	1.35%	25
2024 Q1	$6.01M	Hold	250,000	–	–	1.31%	24
2023 Q4	$4.63M	Sell	250,000 -24,500	-9%	-$403K	1.23%	23
2023 Q3	$3.87M	Sell	274,500 -500	-0.2%	-$7.84K	1.26%	23
2023 Q2	$595K	Buy	275,000 +32,000	+13%	+$600K	0.14%	44
2023 Q1	$5.13M	Hold	243,000	–	–	1.54%	21
2022 Q4	$4.47M	Sell	243,000 -5,000	-2%	-$90.8K	1.55%	19
2022 Q3	$4.44M	Sell	248,000 -15,050	-6%	-$310K	1.83%	19
2022 Q2	$5.86M	Sell	263,050 -7,950	-3%	-$163K	2.64%	14
2022 Q1	$7.58M	Sell	271,000 -67,350	-20%	-$1.54M	2.36%	16
2021 Q4	$7.05M	Hold	338,350	–	–	1.5%	25
2021 Q3	$8.37M	Sell	338,350 -5,250	-2%	-$155K	1.56%	22
2021 Q2	$11.7M	Sell	343,600 -93,900	-21%	-$3.14M	1.94%	15
2021 Q1	$17.9M	Sell	437,500 -17,500	-4%	-$677K	2.62%	11
2020 Q4	$20.1M	Hold	455,000	–	–	2.62%	12
2020 Q3	$8.57M	Buy	455,000 +39,620	+10%	+$743K	1.68%	26
2020 Q2	$8.21M	Buy	415,380 +28,380	+7%	+$623K	1.66%	23
2020 Q1	$7.88M	Buy	387,000 +13,550	+4%	+$313K	2.09%	16
2019 Q4	$10.2M	Sell	373,450 -1,550	-0.4%	-$34.7K	2%	21
2019 Q3	$7.39M	Sell	375,000 -25,000	-6%	-$448K	2.67%	17
2019 Q2	$5.94M	Hold	400,000	–	–	1.81%	24
2019 Q1	$4.95M	Hold	400,000	–	–	1.37%	29
2018 Q4	$5.06M	Buy	400,000 +80,000	+25%	+$1.14M	1.89%	21
2018 Q3	$5.62M	Sell	320,000 -200	-0.1%	-$4.01K	1.43%	24
2018 Q2	$6.68M	Hold	320,200	–	–	1.73%	20
2018 Q1	$6.48M	Hold	320,200	–	–	1.85%	16
2017 Q4	$11.4M	Hold	320,200	–	–	3.65%	7
2017 Q3	$6.29M	Buy	320,200 +3,000	+0.9%	+$33.5K	2.23%	16
2017 Q2	$2.22M	Buy	317,200 +276,800	+685%	+$1.84M	0.93%	29
2017 Q1	$287K	Buy	+40,400	New	+$208K	0.14%	43
2016 Q2	–	Sell	-67,500	Closed	-$1.04M	–	57
2016 Q1	$1.04M	Sell	67,500 -17,500	-21%	-$315K	0.65%	41
2015 Q4	$2.26M	Sell	85,000 -62,500	-42%	-$1.6M	0.95%	38
2015 Q3	$2.22M	Buy	147,500 +115,000	+354%	+$3.63M	1.09%	36
2015 Q2	$2.52M	Buy	+32,500	New	+$2.34M	1%	33

Other funds holding XOMA

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Woodline Partners San Francisco, California $26.4B AUM 44.85% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

GKIM

GW&K Investment Management Boston, Massachusetts $11.3B AUM 31.98% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Opaleye Management's XOMA Position: Q1 2026 in Review

Opaleye Management increased its Xoma (XOMA) stake by 2.5% in Q1 2026, buying an estimated $198K and bringing the position to 300,000 shares worth $9.41M. The position accounts for 1.24% of the portfolio, ranked #23.

Opaleye Management first reported a position in XOMA in Q2 2015 and has held it in 41 quarters since. The position peaked at $20.1M in Q4 2020. 85 funds tracked by Wall St. Rank hold XOMA as of Q1 2026.

Opaleye Management held 300,000 shares of Xoma worth $9.41M as of Q1 2026.
Opaleye Management bought 7,410 Xoma shares in Q1 2026, an estimated $198K.
Xoma made up 1.24% of Opaleye Management's portfolio in Q1 2026, its #23 holding.
Opaleye Management first reported a position in Xoma in Q2 2015 and has held it in 41 quarters since.
Opaleye Management's Xoma position peaked at $20.1M in Q4 2020.
85 funds tracked by Wall St. Rank held Xoma as of Q1 2026.

Based on Opaleye Management's 13F filing for Q1 2026, filed 15 May 2026.