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206 hedge funds and large institutions have $960M invested in Xencor in 2025 Q3 according to their latest regulatory filings, with 34 funds opening new positions, 56 increasing their positions, 81 reducing their positions, and 19 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more first-time investments, than exits

New positions opened: 34 | Existing positions closed: 19

48% more capital invested

Capital invested by funds: $647M → $960M (+$313M)

7% more funds holding

Funds holding: 193206 (+13)

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

0.72% less ownership

Funds ownership: 115.59%114.87% (-0.72%)

31% less repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 81

Holders
206
Holders Change
+13
Holders Change %
+6.74%
% of All Funds
2.7%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
34
Increased
56
Reduced
81
Closed
19
Calls
$116K
Puts
Net Calls
+$116K
Net Calls Change
+$116K
Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$138M -$417K -48,027 -0.4%
Primecap Management
2
Primecap Management
California
$125M +$1.28M +147,700 +1%
Vanguard Group
3
Vanguard Group
Pennsylvania
$83.3M -$13.2M -1,520,616 -18%
RI
4
RTW Investments
New York
$73M +$33.1M +3,818,171 +159%
EC
5
EcoR1 Capital
California
$72.1M
State Street
6
State Street
Massachusetts
$43.1M -$1.25M -143,779 -4%
BI
7
BVF Inc
California
$32.1M
TCM
8
TCG Crossover Management
California
$28.8M
Geode Capital Management
9
Geode Capital Management
Massachusetts
$20.3M +$218K +25,161 +1%
T. Rowe Price Associates
10
T. Rowe Price Associates
Maryland
$19.9M -$17.9M -2,066,892 -55%
Dimensional Fund Advisors
11
Dimensional Fund Advisors
Texas
$18.6M -$1.66M -191,607 -11%
Legal & General Group
12
Legal & General Group
United Kingdom
$14.9M +$9.48M +1,092,095 +604%
B
13
Braidwell
Connecticut
$14.6M -$3.55M -409,410 -25%
UBS Group
14
UBS Group
Switzerland
$13.8M +$3.46M +399,071 +51%
BBA
15
Baker Bros. Advisors
New York
$12.9M +$3.75M +431,675 +64%
NCM
16
Nantahala Capital Management
Connecticut
$12.9M +$2.43M +279,897 +34%
Goldman Sachs
17
Goldman Sachs
New York
$11.9M +$2.61M +301,061 +42%
Morgan Stanley
18
Morgan Stanley
New York
$10.6M -$1.08M -124,561 -12%
Two Sigma Advisers
19
Two Sigma Advisers
New York
$9.5M +$2M +230,900 +40%
Bank of America
20
Bank of America
North Carolina
$8.84M -$1.61M -185,164 -20%
JJ
21
Johnson & Johnson
New Jersey
$8.77M
Northern Trust
22
Northern Trust
Illinois
$8.35M -$31.8K -3,666 -0.5%
Millennium Management
23
Millennium Management
New York
$8.24M +$3.09M +355,640 +103%
Charles Schwab
24
Charles Schwab
California
$8.07M +$774K +89,230 +15%
Two Sigma Investments
25
Two Sigma Investments
New York
$7.38M +$1.64M +189,533 +43%

XNCR Hedge Fund Activity: Q3 2025 in Review

206 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Xencor (XNCR) for Q3 2025, worth a combined $960M — up 48% from $647M a quarter earlier.

Buyers outnumbered sellers: 34 funds opened new XNCR positions and 19 closed out — a net gain of 15 holders — while 56 added to existing stakes and 81 trimmed.

The largest buyer was RTW Investments, adding an estimated $33.1M. The largest seller was T. Rowe Price Associates, cutting an estimated $17.9M.

  • 206 institutional investors held Xencor (XNCR) as of Q3 2025, up from 193 in Q2 2025.
  • Funds reported $960M of Xencor stock for Q3 2025, up 48% quarter-over-quarter.
  • 34 funds opened new Xencor positions in Q3 2025 and 19 closed out, a net change of +15 holders.
  • The largest Xencor buyer in Q3 2025 was RTW Investments, an estimated $33.1M added.
  • The largest Xencor seller in Q3 2025 was T. Rowe Price Associates, an estimated $17.9M sold.

Based on aggregated 13F filings for Q3 2025.