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Xencor
XNCR

208 hedge funds and large institutions have $1.25B invested in Xencor in 2025 Q4 according to their latest regulatory filings, with 35 funds opening new positions, 60 increasing their positions, 78 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

8,692% more call options, than puts

Call options by funds: $1.05M | Put options by funds: $12K

50% more funds holding in top 10

Funds holding in top 10: 2 → 3 (+1)

31% more capital invested

Capital invested by funds: $960M → $1.25B (+$293M)

25% more first-time investments, than exits

New positions opened: 35 | Existing positions closed: 28

1% more funds holding

Funds holding: 206 → 208 (+2)

0.25% less ownership

Funds ownership: 114.87% → 114.63% (-0.25%)

23% less repeat investments, than reductions

Existing positions increased: 60 | Existing positions reduced: 78

Holders
208
Holders Change
+2
Holders Change %
+0.97%
% of All Funds
2.53%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
35
Increased
60
Reduced
78
Closed
28
Calls
$1.05M
Puts
$12K
Net Calls
+$1.04M
Net Calls Change
+$927K

Top Buyers

1
BI
BVF Inc
California
+$65.6M
2
State Street
State Street
Massachusetts
+$12.5M
3
LCM
Lynx1 Capital Management
Puerto Rico
+$10.5M
4
JFG
Jefferies Financial Group
New York
+$9.27M
5
Morgan Stanley
Morgan Stanley
New York
+$9.08M

Top Sellers

1
EC
EcoR1 Capital
California
-$43.2M
2
NCM
Nantahala Capital Management
Connecticut
-$14M
3
B
Braidwell
Connecticut
-$11.8M
4
UBS Group
UBS Group
Switzerland
-$8.03M
5
Primecap Management
Primecap Management
California
-$6.82M
Name Holding Trade Value Shares
Change 		Change in
Stake
Two Sigma Advisers
26
Two Sigma Advisers
New York
$7.76M -$4.54M -303,600 -37%
Toronto Dominion Bank
27
Toronto Dominion Bank
Ontario, Canada
$7.52M +$6.59M +441,000 +882%
EAM
28
Erste Asset Management
Austria
$7.35M +$1.49M +100,000 +26%
B
29
Braidwell
Connecticut
$7.03M -$11.8M -787,114 -63%
Hudson Bay Capital Management
30
Hudson Bay Capital Management
Connecticut
$6.51M -$523K -35,003 -8%
Acadian Asset Management
31
Acadian Asset Management
Massachusetts
$6.3M -$1.8M -120,477 -23%
Bank of New York Mellon
32
Bank of New York Mellon
New York
$6.29M -$226K -15,138 -4%
Barclays
33
Barclays
United Kingdom
$5.5M -$3.6M -241,110 -40%
Principal Financial Group
34
Principal Financial Group
Iowa
$5.21M -$61.7K -4,130 -1%
Citadel Advisors
35
Citadel Advisors
Florida
$4.93M -$2.38M -159,360 -33%
JP Morgan Chase
36
JP Morgan Chase
New York
$4.65M -$1.46M -97,522 -24%
Two Sigma Investments
37
Two Sigma Investments
New York
$4.11M -$5.39M -360,639 -57%
Invesco
38
Invesco
Georgia
$4.07M +$212K +14,216 +6%
Jacobs Levy Equity Management
39
Jacobs Levy Equity Management
New Jersey
$3.97M +$3.87M +259,319 New
Public Sector Pension Investment Board (PSP Investments)
40
Public Sector Pension Investment Board (PSP Investments)
Quebec, Canada
$3.79M -$463K -30,985 -11%
Deutsche Bank
41
Deutsche Bank
Germany
$3.32M +$2.56M +171,335 +379%
NAMI
42
Nomura Asset Management International
Pennsylvania
$3.06M +$2.99M +200,000 New
WP
43
Woodline Partners
California
$2.96M – – –
SPS
44
Susquehanna Portfolio Strategies
Pennsylvania
$2.93M +$1.26M +84,608 +79%
TI
45
Trexquant Investment
Connecticut
$2.68M +$583K +39,042 +29%
American Century Companies
46
American Century Companies
Missouri
$2.67M +$18.2K +1,221 +0.7%
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$2.54M -$150K -10,052 -6%
RPAM
48
Rhenman & Partners Asset Management
Sweden
$2.54M – – –
NCM
49
Nantahala Capital Management
Connecticut
$2.52M -$14M -935,361 -85%
DA
50
DCF Advisers
Connecticut
$2.37M -$523K -35,000 -18%
1
2
3 4 5

XNCR Hedge Fund Activity: Q4 2025 in Review

208 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Xencor (XNCR) for Q4 2025, worth a combined $1.25B — up 31% from $960M a quarter earlier.

Buyers outnumbered sellers: 35 funds opened new XNCR positions and 28 closed out — a net gain of 7 holders — while 60 added to existing stakes and 78 trimmed.

The largest buyer was BVF Inc, adding an estimated $65.6M. The largest seller was EcoR1 Capital, cutting an estimated $43.2M.

  • 208 institutional investors held Xencor (XNCR) as of Q4 2025, up from 206 in Q3 2025.
  • Funds reported $1.25B of Xencor stock for Q4 2025, up 31% quarter-over-quarter.
  • 35 funds opened new Xencor positions in Q4 2025 and 28 closed out, a net change of +7 holders.
  • The largest Xencor buyer in Q4 2025 was BVF Inc, an estimated $65.6M added.
  • The largest Xencor seller in Q4 2025 was EcoR1 Capital, an estimated $43.2M sold.

Based on aggregated 13F filings for Q4 2025.