Xencor
XNCR
208 hedge funds and large institutions have $1.25B invested in Xencor in 2025 Q4 according to their latest regulatory filings, with 35 funds opening new positions, 60 increasing their positions, 78 reducing their positions, and 28 closing their positions.
8,692% more call options, than puts
Call options by funds: $1.05M | Put options by funds: $12K
50% more funds holding in top 10
Funds holding in top 10: 2 → 3 (+1)
31% more capital invested
Capital invested by funds: $960M → $1.25B (+$293M)
25% more first-time investments, than exits
New positions opened: 35 | Existing positions closed: 28
1% more funds holding
Funds holding: 206 → 208 (+2)
0.25% less ownership
Funds ownership: 114.87% → 114.63% (-0.25%)
23% less repeat investments, than reductions
Existing positions increased: 60 | Existing positions reduced: 78
Top Buyers
| 1 |
BI
BVF Inc
San Francisco,
California
|
+$65.6M |
| 2 |
State Street
Boston,
Massachusetts
|
+$12.5M |
| 3 |
LCM
Lynx1 Capital Management
San Juan,
Puerto Rico
|
+$10.5M |
| 4 |
JFG
Jefferies Financial Group
New York
|
+$9.27M |
| 5 |
Morgan Stanley
New York
|
+$9.08M |
Top Sellers
| 1 |
EC
EcoR1 Capital
San Francisco,
California
|
-$43.2M |
| 2 |
NCM
Nantahala Capital Management
New Canaan,
Connecticut
|
-$14M |
| 3 |
B
Braidwell
Stamford,
Connecticut
|
-$11.8M |
| 4 |
UBS Group
Zurich,
Switzerland
|
-$8.03M |
| 5 |
Primecap Management
Pasadena,
California
|
-$6.82M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
226
Amundi
Paris,
France
| – | -$135K | -11,408 | Closed |
|
|
IFU
227
iSAM Funds (UK)
London,
United Kingdom
| – | -$91.9K | -7,838 | Closed |
|
|
N
228
Natixis
Paris,
France
| – | -$22.4K | -1,912 | Closed |
|
229
Optiver Holding
Amsterdam,
Netherlands
| – | -$3.75K | -320 | Closed |
|
|
CT
230
Clearstead Trust
Portland,
Maine
| – | -$599 | -51 | Closed |
|
|
WANY
231
Wealthspire Advisors (New York)
New York
| – | -$364 | -31 | Closed |
|
|
ASN
232
Advisory Services Network
Atlanta,
Georgia
| – | -$246 | -21 | Closed |
|
|
BIA
233
Bell Investment Advisors
Oakland,
California
| – | -$223 | -19 | Closed |
|
|
LFG
234
Larson Financial Group
St Louis,
Missouri
| – | -$12 | -1 | Closed |
|
|
SS
235
SBI Securities
Tokyo,
Japan
| – | -$12 | -1 | Closed |
|
XNCR Hedge Fund Activity: Q4 2025 in Review
208 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Xencor (XNCR) for Q4 2025, worth a combined $1.25B — up 31% from $960M a quarter earlier.
Buyers outnumbered sellers: 35 funds opened new XNCR positions and 28 closed out — a net gain of 7 holders — while 60 added to existing stakes and 78 trimmed.
The largest buyer was BVF Inc, adding an estimated $65.6M. The largest seller was EcoR1 Capital, cutting an estimated $43.2M.
- 208 institutional investors held Xencor (XNCR) as of Q4 2025, up from 206 in Q3 2025.
- Funds reported $1.25B of Xencor stock for Q4 2025, up 31% quarter-over-quarter.
- 35 funds opened new Xencor positions in Q4 2025 and 28 closed out, a net change of +7 holders.
- The largest Xencor buyer in Q4 2025 was BVF Inc, an estimated $65.6M added.
- The largest Xencor seller in Q4 2025 was EcoR1 Capital, an estimated $43.2M sold.
Based on aggregated 13F filings for Q4 2025.