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Xeris Biopharma Holdings
XERS

237 hedge funds and large institutions have $611M invested in Xeris Biopharma Holdings in 2026 Q1 according to their latest regulatory filings, with 48 funds opening new positions, 99 increasing their positions, 55 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed

80% more repeat investments, than reductions

Existing positions increased: 99 | Existing positions reduced: 55

54% more call options, than puts

Call options by funds: $5.19M | Put options by funds: $3.37M

45% more first-time investments, than exits

New positions opened: 48 | Existing positions closed: 33

5% more funds holding

Funds holding: 225 → 237 (+12)

0.25% more ownership

Funds ownership: 60.76% → 61.01% (+0.25%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

23% less capital invested

Capital invested by funds: $791M → $611M (-$180M)

Holders
237
Holders Change
+12
Holders Change %
+5.33%
% of All Funds
2.92%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
48
Increased
99
Reduced
55
Closed
33
Calls
$5.19M
Puts
$3.37M
Net Calls
+$1.81M
Net Calls Change
-$2.54M

Top Buyers

1
AC
Armistice Capital
New York
+$12.7M
2
Millennium Management
Millennium Management
New York
+$9.33M
3
RA
Rosalind Advisors
Ontario, Canada
+$7.43M
4
UBS Group
UBS Group
Switzerland
+$6.93M
5
VC
Voss Capital
Texas
+$6.73M

Top Sellers

1
DCM
Driehaus Capital Management
Illinois
-$13.8M
2
Acadian Asset Management
Acadian Asset Management
Massachusetts
-$7.62M
3
Point72 Asset Management
Point72 Asset Management
Connecticut
-$4.77M
4
Connor, Clark & Lunn Investment Management (CC&L)
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
-$4.32M
5
Prudential Financial
Prudential Financial
New Jersey
-$3.73M
Name Holding Trade Value Shares
Change 		Change in
Stake
LFG
226
Larson Financial Group
Missouri
$603 +$690 +104 New
GI
227
GAMMA Investing
California
$580 +$511 +77 +335%
SS
228
Sunbelt Securities
Texas
$470 – – –
SIC
229
SJS Investment Consulting
Ohio
$366 +$292 +44 +232%
VCM
230
Versant Capital Management
Arizona
$284 +$325 +49 New
SGK
231
Steigerwald Gordon & Koch
Virginia
$215 – – –
APW
232
Atlantic Private Wealth
North Carolina
$174 – – –
IA
233
IFP Advisors
Florida
$35 -$888 -134 -96%
JWM
234
JPL Wealth Management
Colorado
$35 +$40 +6 New
HFS
235
Hughes Financial Services
Virginia
$23 +$27 +4 New
Acadian Asset Management
236
Acadian Asset Management
Massachusetts
– -$7.62M -971,598 Closed
Two Sigma Advisers
237
Two Sigma Advisers
New York
– -$6.67M -849,334 Closed
Norges Bank
238
Norges Bank
Norway
– -$6.29M -800,700 Closed
Point72 Asset Management
239
Point72 Asset Management
Connecticut
– -$4.77M -608,080 Closed
CM
240
Castleark Management
Illinois
– -$3.5M -445,950 Closed
JF
241
Jump Financial
Illinois
– -$2.68M -341,068 Closed
HIS
242
Harvest Investment Services
Illinois
– -$2.3M -292,677 Closed
CAU
243
Caxton Associates (UK)
– -$1.37M -174,102 Closed
Polen Capital Management
244
Polen Capital Management
Florida
– -$1.05M -133,416 Closed
FA
245
Faithward Advisors
Pennsylvania
– -$838K -106,730 Closed
RCAP
246
Resolute Capital Asset Partners
Colorado
– -$785K -100,000 Closed
Calamos Advisors
247
Calamos Advisors
Illinois
– -$778K -99,117 Closed
EI
248
EAM Investors
California
– -$629K -80,154 Closed
DM
249
Deerfield Management
New York
– -$410K -52,230 Closed
AC
250
AXQ Capital
New Jersey
– -$365K -46,454 Closed
7 8 9
10
11

XERS Hedge Fund Activity: Q1 2026 in Review

237 of the 8,125 institutional investors tracked by Wall St. Rank reported a position in Xeris Biopharma Holdings (XERS) for Q1 2026, worth a combined $611M — down 23% from $791M a quarter earlier.

Buyers outnumbered sellers: 48 funds opened new XERS positions and 33 closed out — a net gain of 15 holders — while 99 added to existing stakes and 55 trimmed.

The largest buyer was Armistice Capital, opening a new position worth an estimated $12.7M. The largest seller was Driehaus Capital Management, cutting an estimated $13.8M.

  • 237 institutional investors held Xeris Biopharma Holdings (XERS) as of Q1 2026, up from 225 in Q4 2025.
  • Funds reported $611M of Xeris Biopharma Holdings stock for Q1 2026, down 23% quarter-over-quarter.
  • 48 funds opened new Xeris Biopharma Holdings positions in Q1 2026 and 33 closed out, a net change of +15 holders.
  • The largest Xeris Biopharma Holdings buyer in Q1 2026 was Armistice Capital, an estimated $12.7M added.
  • The largest Xeris Biopharma Holdings seller in Q1 2026 was Driehaus Capital Management, an estimated $13.8M sold.

Based on aggregated 13F filings for Q1 2026.