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Tenaya Therapeutics

97 hedge funds and large institutions have $48.8M invested in Tenaya Therapeutics in 2025 Q4 according to their latest regulatory filings, with 27 funds opening new positions, 30 increasing their positions, 20 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

472% more call options, than puts

Call options by funds: $452K | Put options by funds: $79K

50% more first-time investments, than exits

New positions opened: 27 | Existing positions closed: 18

50% more repeat investments, than reductions

Existing positions increased: 30 | Existing positions reduced: 20

20.02% more ownership

Funds ownership: 21.2%41.22% (+20%)

7% more funds holding

Funds holding: 9197 (+6)

12% less capital invested

Capital invested by funds: $55.6M → $48.8M (-$6.76M)

33% less funds holding in top 10

Funds holding in top 10: 32 (-1)

Holders
97
Holders Change
+6
Holders Change %
+6.59%
% of All Funds
1.18%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.02%
New
27
Increased
30
Reduced
20
Closed
18
Calls
$452K
Puts
$79K
Net Calls
+$373K
Net Calls Change
-$197K
Name Holding Trade Value Shares
Change
Change in
Stake
Two Sigma Advisers
26
Two Sigma Advisers
New York
$281K +$246K +181,000 +85%
CC
27
Casdin Capital
New York
$258K
SCM
28
Stonepine Capital Management
Oregon
$250K +$479K +352,001 New
Susquehanna International Group
29
Susquehanna International Group
Pennsylvania
$202K -$95.4K -70,152 -20%
Northern Trust
30
Northern Trust
Illinois
$172K +$2.84K +2,091 +0.9%
OAC
31
OMERS Administration Corp
Ontario, Canada
$168K +$322K +236,400 New
Morgan Stanley
32
Morgan Stanley
New York
$148K +$56.2K +41,342 +25%
Corient Private Wealth
33
Corient Private Wealth
Florida
$143K +$274K +201,600 New
BCM
34
Bridgeway Capital Management
Texas
$139K +$238K +175,000 +884%
MG
35
Marex Group
$132K -$160K -117,489 -39%
Barclays
36
Barclays
United Kingdom
$132K +$252K +185,000 +18,500,000%
GCM
37
Graham Capital Management
Connecticut
$127K +$243K +178,764 New
Cetera Investment Advisers
38
Cetera Investment Advisers
Illinois
$75.7K +$74.8K +55,000 +107%
XT
39
XTX Topco
Cayman Islands
$75.2K +$10.7K +7,854 +8%
LIP
40
Lighthouse Investment Partners
Florida
$62.3K +$119K +87,600 New
Jacobs Levy Equity Management
41
Jacobs Levy Equity Management
New Jersey
$54K +$103K +75,927 New
Pathstone Holdings
42
Pathstone Holdings
New Jersey
$53.4K
Dimensional Fund Advisors
43
Dimensional Fund Advisors
Texas
$50.1K -$3.98K -2,930 -4%
Goldman Sachs
44
Goldman Sachs
New York
$48.4K -$217K -159,520 -70%
JFG
45
Jefferies Financial Group
New York
$41.4K -$4.17K -3,065 -5%
CFO
46
Callan Family Office
Pennsylvania
$35.6K +$18.8K +13,792 +38%
Charles Schwab
47
Charles Schwab
California
$35.6K
VPIM
48
Vanguard Personalized Indexing Management
California
$32.7K +$203 +149 +0.3%
AWM
49
Atticus Wealth Management
Florida
$30.8K -$2.21K -1,625 -4%
Simplex Trading
50
Simplex Trading
Illinois
$27.4K -$99.8K -73,389 -66%

TNYA Hedge Fund Activity: Q4 2025 in Review

97 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Tenaya Therapeutics (TNYA) for Q4 2025, worth a combined $48.8M — down 12% from $55.6M a quarter earlier.

Buyers outnumbered sellers: 27 funds opened new TNYA positions and 18 closed out — a net gain of 9 holders — while 30 added to existing stakes and 20 trimmed.

The largest buyer was Citadel Advisors, opening a new position worth an estimated $5.71M. The largest seller was Aberdeen Group, exiting entirely with an estimated $973K sold.

  • 97 institutional investors held Tenaya Therapeutics (TNYA) as of Q4 2025, up from 91 in Q3 2025.
  • Funds reported $48.8M of Tenaya Therapeutics stock for Q4 2025, down 12% quarter-over-quarter.
  • 27 funds opened new Tenaya Therapeutics positions in Q4 2025 and 18 closed out, a net change of +9 holders.
  • The largest Tenaya Therapeutics buyer in Q4 2025 was Citadel Advisors, an estimated $5.71M added.
  • The largest Tenaya Therapeutics seller in Q4 2025 was Aberdeen Group, an estimated $973K sold.

Based on aggregated 13F filings for Q4 2025.