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Tango Therapeutics

122 hedge funds and large institutions have $147M invested in Tango Therapeutics in 2025 Q1 according to their latest regulatory filings, with 15 funds opening new positions, 43 increasing their positions, 39 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

10% more repeat investments, than reductions

Existing positions increased: 43 | Existing positions reduced: 39

0.15% more ownership

Funds ownership: 99.09%99.24% (+0.15%)

11% less funds holding

Funds holding: 137122 (-15)

33% less funds holding in top 10

Funds holding in top 10: 64 (-2)

50% less first-time investments, than exits

New positions opened: 15 | Existing positions closed: 30

55% less capital invested

Capital invested by funds: $329M → $147M (-$182M)

Holders
122
Holders Change
-15
Holders Change %
-10.95%
% of All Funds
1.64%
Holding in Top 10
4
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-33.33%
% of All Funds
0.05%
New
15
Increased
43
Reduced
39
Closed
30
Calls
$2K
Puts
Net Calls
+$2K
Net Calls Change
+$12K
Name Holding Trade Value Shares
Change
Change in
Stake
Dimensional Fund Advisors
26
Dimensional Fund Advisors
Texas
$830K -$141K -57,486 -9%
O
27
OrbiMed
New York
$754K
Charles Schwab
28
Charles Schwab
California
$751K +$84.9K +34,585 +7%
WP
29
Woodline Partners
California
$693K +$275K +111,791 +28%
Northern Trust
30
Northern Trust
Illinois
$616K -$156K -63,697 -12%
Jane Street
31
Jane Street
New York
$483K +$633K +257,668 +271%
Bank of America
32
Bank of America
North Carolina
$482K +$195K +79,256 +29%
DekaBank Deutsche Girozentrale
33
DekaBank Deutsche Girozentrale
Germany
$463K
Morgan Stanley
34
Morgan Stanley
New York
$343K -$171K -69,551 -22%
GCP
35
GSA Capital Partners
United Kingdom
$331K +$381K +155,284 +180%
SFI
36
Susquehanna Fundamental Investments
Pennsylvania
$319K -$281K -114,505 -33%
CAM
37
Congress Asset Management
Massachusetts
$311K -$1.54K -628 -0.3%
Fisher Asset Management
38
Fisher Asset Management
Washington
$307K +$170K +69,130 +45%
Walleye Capital
39
Walleye Capital
New York
$290K -$185K -75,255 -26%
N
40
Nuveen
North Carolina
$277K +$24.4K +9,924 +5%
TGV
41
TRV GP VI
Massachusetts
$266K
Renaissance Technologies
42
Renaissance Technologies
New York
$239K +$376K +153,000 +712%
Goldman Sachs
43
Goldman Sachs
New York
$236K -$772K -314,455 -65%
XT
44
XTX Topco
Cayman Islands
$230K +$222K +90,208 +116%
UBS Group
45
UBS Group
Switzerland
$210K -$641K -261,138 -63%
AQR Capital Management
46
AQR Capital Management
Connecticut
$195K +$349K +142,108 New
Los Angeles Capital Management
47
Los Angeles Capital Management
California
$177K +$144K +58,658 +83%
CC
48
Casdin Capital
New York
$171K -$2.61M -1,063,349 -89%
BCM
49
Bridgeway Capital Management
Texas
$171K +$307K +125,000 New
Franklin Resources
50
Franklin Resources
California
$171K -$4.15K -1,688 -1%

TNGX Hedge Fund Activity: Q1 2025 in Review

122 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Tango Therapeutics (TNGX) for Q1 2025, worth a combined $147M — down 55% from $329M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of TNGX and 15 opened new positions — a net loss of 15 holders — while 39 trimmed existing stakes and 43 added.

The largest buyer was Marshall Wace, opening a new position worth an estimated $4.52M. The largest seller was Citadel Advisors, cutting an estimated $3.73M.

  • 122 institutional investors held Tango Therapeutics (TNGX) as of Q1 2025, down from 137 in Q4 2024.
  • Funds reported $147M of Tango Therapeutics stock for Q1 2025, down 55% quarter-over-quarter.
  • 15 funds opened new Tango Therapeutics positions in Q1 2025 and 30 closed out, a net change of -15 holders.
  • The largest Tango Therapeutics buyer in Q1 2025 was Marshall Wace, an estimated $4.52M added.
  • The largest Tango Therapeutics seller in Q1 2025 was Citadel Advisors, an estimated $3.73M sold.

Based on aggregated 13F filings for Q1 2025.