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Name Holding Trade Value Shares
Change
Change in
Stake
EWM
1
Essex Woodlands Management
Texas
$25M +$2.07M +249,473 +8%
O
2
OrbiMed
New York
$21.2M
OM
3
Opaleye Management
Massachusetts
$11.5M +$9.68M +1,166,367 +245%
RI
4
RTW Investments
New York
$7.13M
IV
5
Industry Ventures
California
$4.06M +$4.81M +579,745 New
PVI
6
Pura Vida Investments
New York
$3.9M -$98K -11,797 -2%
VCIM
7
Velan Capital Investment Management
Georgia
$3.49M +$389K +46,838 +10%
Vanguard Group
8
Vanguard Group
Pennsylvania
$2.75M
PCM
9
Pentwater Capital Management
Florida
$2.73M +$646K +77,762 +25%
ACM
10
AIGH Capital Management
Maryland
$2.16M +$2.54M +306,464 New
HLA
11
Hamilton Lane Advisors
Pennsylvania
$1.85M +$2.2M +264,366 New
GPCM
12
Granite Point Capital Management
Massachusetts
$1.6M
JG
13
Jefferies Group
New York
$1.02M +$1.21M +145,507 New
SSA
14
Schonfeld Strategic Advisors
New York
$984K -$44.5K -5,364 -4%
WVP
15
Worth Venture Partners
New Jersey
$904K +$938K +113,012 New
JAMONY
16
Jacob Asset Management of New York
California
$825K -$107K -12,899 -10%
PHP
17
Parkman Healthcare Partners
Connecticut
$764K +$3.98K +480 +0.4%
SMH
18
Sanders Morris Harris
Texas
$674K -$74.7K -9,000 -9%
BCM
19
Bridgeway Capital Management
Texas
$547K +$125K +15,000 +24%
Geode Capital Management
20
Geode Capital Management
Massachusetts
$486K +$28.6K +3,447 +5%
PNC Financial Services Group
21
PNC Financial Services Group
Pennsylvania
$376K +$53.4K +6,433 +14%
Millennium Management
22
Millennium Management
New York
$272K +$318K +38,263 New
WP
23
WMS Partners
Maryland
$197K
State Street
24
State Street
Massachusetts
$185K
BlackRock
25
BlackRock
New York
$103K -$56.4K -6,798 -32%