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Name Holding Trade Value Shares
Change 		Change in
Stake
CG
1
Column Group
California
$65.5M +$86.8M +616,542 New
BBA
2
Baker Bros. Advisors
New York
$17.7M +$23.5M +166,667 New
HA
3
HHLR Advisors
Cayman Islands
$8.5M +$11.3M +80,000 New
CCM
4
Consonance Capital Management
New York
$6.72M +$9.38M +66,667 New
HMC
5
Harvard Management Company
Massachusetts
$5.85M +$7.76M +55,123 New
BOTOTLSJU
6
Board of Trustees of The Leland Stanford Junior University
California
$5.71M +$7.57M +53,758 New
EC
7
Euclidean Capital
New York
$5.68M +$7.53M +53,531 New
TOCUITCONY
8
Trustees of Columbia University in the City of New York
New York
$5.09M +$6.75M +47,930 New
Vanguard Group
9
Vanguard Group
Pennsylvania
$4.4M +$5.83M +41,416 New
BM
10
Bridger Management
New York
$4.19M +$6.57M +46,667 New
MIM
11
Monashee Investment Management
Massachusetts
$3.54M +$4.69M +33,333 New
PA
12
Perceptive Advisors
New York
$3.54M +$4.69M +33,333 New
Alyeska Investment Group
13
Alyeska Investment Group
Illinois
$2.96M +$2.35M +16,666 +100%
LCM
14
Laurion Capital Management
New York
$2.62M +$3.47M +24,667 New
SB
15
Samsara BioCapital
California
$2.12M +$2.81M +20,000 New
Hudson Bay Capital Management
16
Hudson Bay Capital Management
Connecticut
$2.11M +$938K +6,667 +50%
BC
17
Boxer Capital
California
$1.42M +$1.88M +13,333 New
Geode Capital Management
18
Geode Capital Management
Massachusetts
$910K +$1.21M +8,569 New
PCM
19
Prelude Capital Management
New York
$523K +$693K +4,923 New
State Street
20
State Street
Massachusetts
$476K +$632K +4,487 New
JRP
21
Jasper Ridge Partners
California
$332K +$440K +3,123 New
Northern Trust
22
Northern Trust
Illinois
$269K +$357K +2,533 New
BlackRock
23
BlackRock
New York
$248K +$328K +2,331 New
VF
24
Virtu Financial
New York
$159K +$211K +1,497 New
HCM
25
Highbridge Capital Management
New York
$83K +$110K +780 New
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