|
1
|
Vanguard Group
Malvern,
Pennsylvania
|
$1.14B
|
-$2.5M
|
-20,370
|
-0.2%
|
|
|
2
|
|
$772M
|
-$30.8M
|
-251,422
|
-4%
|
|
|
3
|
Janus Henderson Group
London,
|
$633M
|
-$55.7M
|
-454,368
|
-8%
|
|
|
4
|
Capital International Investors
Los Angeles,
California
|
$624M
|
+$9.31M
|
+76,032
|
+2%
|
|
|
5
|
Avoro Capital Advisors
New York
|
$562M
|
–
|
–
|
–
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$420M
|
-$108M
|
-881,812
|
-21%
|
|
|
7
|
Farallon Capital Management
San Francisco,
California
|
$318M
|
+$152M
|
+1,243,427
|
+103%
|
|
|
8
|
State Street
Boston,
Massachusetts
|
$275M
|
-$33.9M
|
-276,587
|
-12%
|
|
|
9
|
Bank of New York Mellon
New York
|
$268M
|
-$32.2M
|
-262,519
|
-11%
|
|
|
10
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$250M
|
+$1.45M
|
+11,805
|
+0.6%
|
|
|
11
|
EcoR1 Capital
San Francisco,
California
|
$249M
|
+$133M
|
+1,086,928
|
+130%
|
|
|
12
|
|
$237M
|
+$64.4M
|
+526,045
|
+40%
|
|
|
13
|
Citadel Advisors
Miami,
Florida
|
$197M
|
+$22.1M
|
+180,347
|
+13%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$197M
|
+$6.23M
|
+50,833
|
+3%
|
|
|
15
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$189M
|
-$1.77M
|
-14,487
|
-1%
|
|
|
16
|
Fidelity Investments
Boston,
Massachusetts
|
$175M
|
-$19.4M
|
-158,494
|
-11%
|
|
|
17
|
Pictet Asset Management
Carouge,
Switzerland
|
$163M
|
+$20.4M
|
+166,934
|
+15%
|
|
|
18
|
Paradigm Biocapital Advisors
New York
|
$140M
|
+$132M
|
+1,078,346
|
New
|
|
|
19
|
|
$138M
|
+$7.66M
|
+62,500
|
+6%
|
|
|
20
|
|
$125M
|
+$16.2M
|
+131,949
|
+16%
|
|
|
21
|
|
$115M
|
-$60.2M
|
-491,716
|
-36%
|
|
|
22
|
Millennium Management
New York
|
$113M
|
+$28.2M
|
+230,009
|
+36%
|
|
|
23
|
|
$90.3M
|
–
|
–
|
–
|
|
|
24
|
Two Sigma Advisers
New York
|
$85.6M
|
-$5.49M
|
-44,800
|
-6%
|
|
|
25
|
Bank of America
Charlotte,
North Carolina
|
$84.6M
|
-$68.5M
|
-558,912
|
-46%
|
|
