SOPHiA GENETICS
SOPH
49 hedge funds and large institutions have $120M invested in SOPHiA GENETICS in 2026 Q1 according to their latest regulatory filings, with 17 funds opening new positions, 11 increasing their positions, 8 reducing their positions, and 10 closing their positions.
2,890% more call options, than puts
Call options by funds: $299K | Put options by funds: $10K
70% more first-time investments, than exits
New positions opened: 17 | Existing positions closed: 10
41% more capital invested
Capital invested by funds: $85.5M → $120M (+$34.9M)
38% more repeat investments, than reductions
Existing positions increased: 11 | Existing positions reduced: 8
17% more funds holding
Funds holding: 42 → 49 (+7)
8.41% more ownership
Funds ownership: 27.1% → 35.51% (+8.4%)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
+$9M |
| 2 |
RA
Royce & Associates
New York
|
+$6.74M |
| 3 |
KCM
Kennedy Capital Management
St Louis,
Missouri
|
+$4.51M |
| 4 |
EIM
Essex Investment Management
Boston,
Massachusetts
|
+$3.37M |
| 5 |
HCM
Hodges Capital Management
Dallas,
Texas
|
+$2.12M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
-$561K |
| 2 |
Morgan Stanley
New York
|
-$121K |
| 3 |
GCP
GSA Capital Partners
London,
United Kingdom
|
-$117K |
| 4 |
Renaissance Technologies
New York
|
-$113K |
| 5 |
Polen Capital Management
Boca Raton,
Florida
|
-$102K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
51
Polen Capital Management
Boca Raton,
Florida
| – | -$102K | -21,738 | Closed |
|
|
FIA
52
FNY Investment Advisers
New York
| – | -$74K | -16,010 | Closed |
|
|
XT
53
XTX Topco
George Town,
Cayman Islands
| – | -$54.9K | -11,760 | Closed |
|
|
QC
54
Quadrature Capital
London,
United Kingdom
| – | -$54.4K | -11,649 | Closed |
|
55
Acadian Asset Management
Boston,
Massachusetts
| – | -$27K | -5,911 | Closed |
|
56
Bank of America
Charlotte,
North Carolina
| – | -$25.9K | -5,552 | Closed |
|
57
PNC Financial Services Group
Pittsburgh,
Pennsylvania
| – | -$1.73K | -370 | Closed |
|
|
UFPG
58
United Financial Planning Group
Hauppauge,
New York
| – | -$794 | -170 | Closed |
|
59
Simplex Trading
Chicago,
Illinois
| – | -$151 | -31 | Closed |
|
SOPH Hedge Fund Activity: Q1 2026 in Review
49 of the 8,130 institutional investors tracked by Wall St. Rank reported a position in SOPHiA GENETICS (SOPH) for Q1 2026, worth a combined $120M — up 41% from $85.5M a quarter earlier.
Buyers outnumbered sellers: 17 funds opened new SOPH positions and 10 closed out — a net gain of 7 holders — while 11 added to existing stakes and 8 trimmed.
The largest buyer was Soleus Capital Management, opening a new position worth an estimated $9M. The largest seller was Millennium Management, cutting an estimated $561K.
- 49 institutional investors held SOPHiA GENETICS (SOPH) as of Q1 2026, up from 42 in Q4 2025.
- Funds reported $120M of SOPHiA GENETICS stock for Q1 2026, up 41% quarter-over-quarter.
- 17 funds opened new SOPHiA GENETICS positions in Q1 2026 and 10 closed out, a net change of +7 holders.
- The largest SOPHiA GENETICS buyer in Q1 2026 was Soleus Capital Management, an estimated $9M added.
- The largest SOPHiA GENETICS seller in Q1 2026 was Millennium Management, an estimated $561K sold.
Based on aggregated 13F filings for Q1 2026.