SOPHiA GENETICS
SOPH
42 hedge funds and large institutions have $85.5M invested in SOPHiA GENETICS in 2025 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 16 increasing their positions, 7 reducing their positions, and 8 closing their positions.
129% more repeat investments, than reductions
Existing positions increased: 16 | Existing positions reduced: 7
25% more first-time investments, than exits
New positions opened: 10 | Existing positions closed: 8
5% more funds holding
Funds holding: 40 → 42 (+2)
1% more capital invested
Capital invested by funds: $84.3M → $85.5M (+$1.22M)
0.89% more ownership
Funds ownership: 26.21% → 27.1% (+0.89%)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RA
Royce & Associates
New York
|
+$1.95M |
| 2 |
1CM
1492 Capital Management
Milwaukee,
Wisconsin
|
+$944K |
| 3 |
Renaissance Technologies
New York
|
+$236K |
| 4 |
UBS Group
Zurich,
Switzerland
|
+$211K |
| 5 |
Polen Capital Management
Boca Raton,
Florida
|
+$98.5K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
-$455K |
| 2 |
Dimensional Fund Advisors
Austin,
Texas
|
-$148K |
| 3 |
TSW
Thompson Siegel & Walmsley
Richmond,
Virginia
|
-$142K |
| 4 |
FIA
FNY Investment Advisers
New York
|
-$130K |
| 5 |
Federated Hermes
Pittsburgh,
Pennsylvania
|
-$101K |
SOPH Hedge Fund Activity: Q4 2025 in Review
42 of the 8,225 institutional investors tracked by Wall St. Rank reported a position in SOPHiA GENETICS (SOPH) for Q4 2025, worth a combined $85.5M — up 1.4% from $84.3M a quarter earlier.
Buyers outnumbered sellers: 10 funds opened new SOPH positions and 8 closed out — a net gain of 2 holders — while 16 added to existing stakes and 7 trimmed.
The largest buyer was Royce & Associates, opening a new position worth an estimated $1.95M. The largest seller was Millennium Management, cutting an estimated $455K.
- 42 institutional investors held SOPHiA GENETICS (SOPH) as of Q4 2025, up from 40 in Q3 2025.
- Funds reported $85.5M of SOPHiA GENETICS stock for Q4 2025, up 1.4% quarter-over-quarter.
- 10 funds opened new SOPHiA GENETICS positions in Q4 2025 and 8 closed out, a net change of +2 holders.
- The largest SOPHiA GENETICS buyer in Q4 2025 was Royce & Associates, an estimated $1.95M added.
- The largest SOPHiA GENETICS seller in Q4 2025 was Millennium Management, an estimated $455K sold.
Based on aggregated 13F filings for Q4 2025.