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SOPHiA GENETICS
SOPH

40 hedge funds and large institutions have $84.3M invested in SOPHiA GENETICS in 2025 Q3 according to their latest regulatory filings, with 11 funds opening new positions, 11 increasing their positions, 8 reducing their positions, and 3 closing their positions.

New
Increased
Maintained
Reduced
Closed

267% more first-time investments, than exits

New positions opened: 11 | Existing positions closed: 3

65% more capital invested

Capital invested by funds: $51.2M → $84.3M (+$33.1M)

38% more repeat investments, than reductions

Existing positions increased: 11 | Existing positions reduced: 8

25% more funds holding

Funds holding: 32 → 40 (+8)

1.43% more ownership

Funds ownership: 24.78% → 26.21% (+1.4%)

Holders
40
Holders Change
+8
Holders Change %
+25%
% of All Funds
0.52%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
11
Increased
11
Reduced
8
Closed
3
Calls
$164K
Puts
–
Net Calls
+$164K
Net Calls Change
+$151K

Top Buyers

Rank Fund Capital Flow
1
AWA
Alta Wealth Advisors
Massachusetts
+$4.84M
2
ACM
Archon Capital Management
Washington
+$363K
3
FIA
FNY Investment Advisers
New York
+$154K
4
TSW
Thompson Siegel & Walmsley
Virginia
+$102K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$63.5K

Top Sellers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
-$1.23M
2
Ensign Peak Advisors
Ensign Peak Advisors
Utah
-$188K
3
RI
Ridgewood Investments
New Jersey
-$107K
4
Citadel Advisors
Citadel Advisors
Florida
-$92.1K
5
Federated Hermes
Federated Hermes
Pennsylvania
-$34.4K
Name Holding Trade Value Shares
Change 		Change in
Stake
Citadel Advisors
26
Citadel Advisors
Florida
$58.6K -$92.1K -26,791 -68%
Squarepoint
27
Squarepoint
New York
$48.7K +$35.2K +10,231 New
SAI
28
Savvy Advisors Inc
New York
$47.6K +$34.4K +10,000 New
Zurich Cantonal Bank
29
Zurich Cantonal Bank
Switzerland
$33K +$3.22K +938 +16%
BlackRock
30
BlackRock
New York
$24.2K +$368 +107 +2%
AssetMark Inc
31
AssetMark Inc
California
$19.6K +$7.93K +2,307 +127%
CLOS
32
Compagnie Lombard Odier SCmA
Switzerland
$5.02K – – –
Simplex Trading
33
Simplex Trading
Illinois
$4K +$3.53K +1,026 New
Royal Bank of Canada
34
Royal Bank of Canada
Ontario, Canada
$3K – – –
TRCT
35
Tower Research Capital (TRC)
New York
$2.34K +$1.69K +491 New
PS
36
Principal Securities
Iowa
$1.88K – – –
Osaic Holdings
37
Osaic Holdings
Arizona
$700 +$316 +92 +167%
GLF
38
Groupe la Francaise
France
$569 +$412 +120 New
Russell Investments Group
39
Russell Investments Group
United Kingdom
$105 – – –
SS
40
SBI Securities
Japan
$5 +$3 +1 New
RI
41
Ridgewood Investments
New Jersey
– -$107K -34,449 Closed
Citigroup
42
Citigroup
New York
– -$4.31K -1,389 Closed
JP Morgan Chase
43
JP Morgan Chase
New York
– -$614 -198 Closed
1
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SOPH Hedge Fund Activity: Q3 2025 in Review

40 of the 7,622 institutional investors tracked by Wall St. Rank reported a position in SOPHiA GENETICS (SOPH) for Q3 2025, worth a combined $84.3M — up 65% from $51.2M a quarter earlier.

Buyers outnumbered sellers: 11 funds opened new SOPH positions and 3 closed out — a net gain of 8 holders — while 11 added to existing stakes and 8 trimmed.

The largest buyer was Alta Wealth Advisors, opening a new position worth an estimated $4.84M. The largest seller was Millennium Management, cutting an estimated $1.23M.

  • 40 institutional investors held SOPHiA GENETICS (SOPH) as of Q3 2025, up from 32 in Q2 2025.
  • Funds reported $84.3M of SOPHiA GENETICS stock for Q3 2025, up 65% quarter-over-quarter.
  • 11 funds opened new SOPHiA GENETICS positions in Q3 2025 and 3 closed out, a net change of +8 holders.
  • The largest SOPHiA GENETICS buyer in Q3 2025 was Alta Wealth Advisors, an estimated $4.84M added.
  • The largest SOPHiA GENETICS seller in Q3 2025 was Millennium Management, an estimated $1.23M sold.

Based on aggregated 13F filings for Q3 2025.