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Syndax Pharmaceuticals
SNDX

229 hedge funds and large institutions have $2.1B invested in Syndax Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 83 increasing their positions, 80 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

108% more call options, than puts

Call options by funds: $30M | Put options by funds: $14.4M

35% more capital invested

Capital invested by funds: $1.56B → $2.1B (+$543M)

22% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 27

10% more funds holding in top 10

Funds holding in top 10: 10 → 11 (+1)

4% more repeat investments, than reductions

Existing positions increased: 83 | Existing positions reduced: 80

1% more funds holding

Funds holding: 227 → 229 (+2)

2.44% less ownership

Funds ownership: 117.38% → 114.94% (-2.4%)

Holders
229
Holders Change
+2
Holders Change %
+0.88%
% of All Funds
2.78%
Holding in Top 10
11
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+10%
% of All Funds
0.13%
New
33
Increased
83
Reduced
80
Closed
27
Calls
$30M
Puts
$14.4M
Net Calls
+$15.6M
Net Calls Change
+$3.08M

Top Buyers

1
HRCM
Hood River Capital Management
Florida
+$40.4M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$19M
3
Bank of America
Bank of America
North Carolina
+$17.7M
4
Ensign Peak Advisors
Ensign Peak Advisors
Utah
+$13.8M
5
State Street
State Street
Massachusetts
+$13M

Top Sellers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$51M
2
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
-$30.4M
3
Millennium Management
Millennium Management
New York
-$17.3M
4
UBS Group
UBS Group
Switzerland
-$16.7M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$16.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
VCM
201
Versant Capital Management
Arizona
$17.7K – – –
IA
202
IFP Advisors
Florida
$16.6K +$12.9K +740 +1,451%
Comerica Bank
203
Comerica Bank
Texas
$15.1K – – –
FFA
204
Farther Finance Advisors
California
$11.4K +$8.79K +504 +1,362%
Rockefeller Capital Management
205
Rockefeller Capital Management
New York
$9.92K +$8.23K +472 New
JFG
206
Jefferies Financial Group
New York
$8.68K -$150K -8,587 -95%
TC
207
Truvestments Capital
Florida
$6.95K – – –
SPIA
208
Steward Partners Investment Advisory
New York
$6.95K +$1.75K +100 +43%
AAP
209
Arax Advisory Partners
Colorado
$6.66K -$79.9K -4,580 -94%
CMBA
210
C.M. Bidwell & Associates
Hawaii
$6.47K – – –
GI
211
GAMMA Investing
California
$5.88K +$1.66K +95 +51%
Jones Financial Companies
212
Jones Financial Companies
Missouri
$5.78K – – –
GRP
213
Global Retirement Partners
California
$5.64K +$1.94K +111 +70%
TWD
214
True Wealth Design
Ohio
$5.48K +$907 +52 +25%
SS
215
Sunbelt Securities
Texas
$5.46K +$523 +30 +13%
Daiwa Securities Group
216
Daiwa Securities Group
Japan
$5K -$1.22K -70 -22%
SS
217
SBI Securities
Japan
$4.26K +$17 +1 +0.5%
Optiver Holding
218
Optiver Holding
Netherlands
$3.53K -$9.61K -551 -77%
BBHC
219
Brown Brothers Harriman & Co
New York
$2.69K – – –
RIL
220
Rothschild Investment LLC
Illinois
$2.63K +$523 +30 +32%
AW
221
Avion Wealth
Texas
$2K – – –
BAM
222
Bellevue Asset Management
Washington
$1.66K – – –
MPWT
223
MassMutual Private Wealth & Trust
Connecticut
$1.49K – – –
SIC
224
SJS Investment Consulting
Ohio
$1.16K +$960 +55 New
AssetMark Inc
225
AssetMark Inc
California
$840 – – –
7 8
9
10 11

SNDX Hedge Fund Activity: Q4 2025 in Review

229 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Syndax Pharmaceuticals (SNDX) for Q4 2025, worth a combined $2.1B — up 35% from $1.56B a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new SNDX positions and 27 closed out — a net gain of 6 holders — while 83 added to existing stakes and 80 trimmed.

The largest buyer was Hood River Capital Management, opening a new position worth an estimated $40.4M. The largest seller was Adage Capital Partners, exiting entirely with an estimated $51M sold.

  • 229 institutional investors held Syndax Pharmaceuticals (SNDX) as of Q4 2025, up from 227 in Q3 2025.
  • Funds reported $2.1B of Syndax Pharmaceuticals stock for Q4 2025, up 35% quarter-over-quarter.
  • 33 funds opened new Syndax Pharmaceuticals positions in Q4 2025 and 27 closed out, a net change of +6 holders.
  • The largest Syndax Pharmaceuticals buyer in Q4 2025 was Hood River Capital Management, an estimated $40.4M added.
  • The largest Syndax Pharmaceuticals seller in Q4 2025 was Adage Capital Partners, an estimated $51M sold.

Based on aggregated 13F filings for Q4 2025.