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Syndax Pharmaceuticals
SNDX

229 hedge funds and large institutions have $2.1B invested in Syndax Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 83 increasing their positions, 80 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

108% more call options, than puts

Call options by funds: $30M | Put options by funds: $14.4M

35% more capital invested

Capital invested by funds: $1.56B → $2.1B (+$543M)

22% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 27

10% more funds holding in top 10

Funds holding in top 10: 10 → 11 (+1)

4% more repeat investments, than reductions

Existing positions increased: 83 | Existing positions reduced: 80

1% more funds holding

Funds holding: 227 → 229 (+2)

2.44% less ownership

Funds ownership: 117.38% → 114.94% (-2.4%)

Holders
229
Holders Change
+2
Holders Change %
+0.88%
% of All Funds
2.78%
Holding in Top 10
11
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+10%
% of All Funds
0.13%
New
33
Increased
83
Reduced
80
Closed
27
Calls
$30M
Puts
$14.4M
Net Calls
+$15.6M
Net Calls Change
+$3.08M

Top Buyers

1
HRCM
Hood River Capital Management
Florida
+$40.4M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$19M
3
Bank of America
Bank of America
North Carolina
+$17.7M
4
Ensign Peak Advisors
Ensign Peak Advisors
Utah
+$13.8M
5
State Street
State Street
Massachusetts
+$13M

Top Sellers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$51M
2
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
-$30.4M
3
Millennium Management
Millennium Management
New York
-$17.3M
4
UBS Group
UBS Group
Switzerland
-$16.7M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$16.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
XT
151
XTX Topco
Cayman Islands
$388K -$208K -11,917 -39%
Verition Fund Management
152
Verition Fund Management
Connecticut
$388K +$22.3K +1,281 +7%
Susquehanna International Group
153
Susquehanna International Group
Pennsylvania
$381K -$290K -16,597 -48%
Mercer Global Advisors
154
Mercer Global Advisors
Colorado
$374K +$311K +17,805 New
Allspring Global Investments
155
Allspring Global Investments
North Carolina
$374K +$25.4K +1,455 +9%
KK
156
KLP Kapitalforvaltning
Norway
$370K +$17.4K +1,000 +6%
ET
157
Entropy Technologies
New York
$316K +$263K +15,064 New
MG
158
Marex Group
$316K +$263K +15,060 New
QC
159
Quadrature Capital
United Kingdom
$313K -$305K -17,474 -54%
WG
160
Winton Group
United Kingdom
$306K -$139K -7,947 -35%
GC
161
Guggenheim Capital
Illinois
$305K +$41.8K +2,395 +20%
BNP Paribas Financial Markets
162
BNP Paribas Financial Markets
France
$299K -$10.2M -585,643 -98%
CUAMC
163
China Universal Asset Management Company
China
$298K -$16.3K -936 -6%
Lazard Asset Management
164
Lazard Asset Management
New York
$297K +$247K +14,140 New
A
165
AlphaQuest
New York
$292K -$792K -45,420 -77%
Public Employees Retirement Association of Colorado
166
Public Employees Retirement Association of Colorado
Colorado
$289K – – –
SSA
167
Schonfeld Strategic Advisors
New York
$275K -$2.08M -119,023 -90%
Pictet Asset Management
168
Pictet Asset Management
Switzerland
$260K – – –
Teacher Retirement System of Texas
169
Teacher Retirement System of Texas
Texas
$255K -$138K -7,920 -40%
ACM
170
ADAR1 Capital Management
Texas
$252K +$209K +12,000 New
Group One Trading
171
Group One Trading
Illinois
$248K +$206K +11,792 New
Raymond James Financial
172
Raymond James Financial
Florida
$234K +$2.76K +158 +1%
DT
173
Diversified Trust
Tennessee
$233K +$194K +11,109 New
PCA
174
Pallas Capital Advisors
Massachusetts
$231K +$15.3K +875 +9%
I
175
InceptionR
California
$226K +$187K +10,747 New
5 6
7
8 9

SNDX Hedge Fund Activity: Q4 2025 in Review

229 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Syndax Pharmaceuticals (SNDX) for Q4 2025, worth a combined $2.1B — up 35% from $1.56B a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new SNDX positions and 27 closed out — a net gain of 6 holders — while 83 added to existing stakes and 80 trimmed.

The largest buyer was Hood River Capital Management, opening a new position worth an estimated $40.4M. The largest seller was Adage Capital Partners, exiting entirely with an estimated $51M sold.

  • 229 institutional investors held Syndax Pharmaceuticals (SNDX) as of Q4 2025, up from 227 in Q3 2025.
  • Funds reported $2.1B of Syndax Pharmaceuticals stock for Q4 2025, up 35% quarter-over-quarter.
  • 33 funds opened new Syndax Pharmaceuticals positions in Q4 2025 and 27 closed out, a net change of +6 holders.
  • The largest Syndax Pharmaceuticals buyer in Q4 2025 was Hood River Capital Management, an estimated $40.4M added.
  • The largest Syndax Pharmaceuticals seller in Q4 2025 was Adage Capital Partners, an estimated $51M sold.

Based on aggregated 13F filings for Q4 2025.