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Syndax Pharmaceuticals

216 hedge funds and large institutions have $953M invested in Syndax Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 31 funds opening new positions, 86 increasing their positions, 66 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed

30% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 66

15% more call options, than puts

Call options by funds: $14.4M | Put options by funds: $12.5M

0.86% more ownership

Funds ownership: 117.37%118.22% (+0.86%)

1% less funds holding

Funds holding: 218216 (-2)

3% less first-time investments, than exits

New positions opened: 31 | Existing positions closed: 32

24% less capital invested

Capital invested by funds: $1.25B → $953M (-$302M)

30% less funds holding in top 10

Funds holding in top 10: 107 (-3)

Holders
216
Holders Change
-2
Holders Change %
-0.92%
% of All Funds
2.84%
Holding in Top 10
7
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-30%
% of All Funds
0.09%
New
31
Increased
86
Reduced
66
Closed
32
Calls
$14.4M
Puts
$12.5M
Net Calls
+$1.84M
Net Calls Change
-$8.34M
Name Holding Trade Value Shares
Change
Change in
Stake
Two Sigma Advisers
51
Two Sigma Advisers
New York
$3.68M -$1.22M -110,700 -22%
Barclays
52
Barclays
United Kingdom
$3.59M +$2.01M +182,977 +91%
JF
53
Jump Financial
Illinois
$3.57M +$4.19M +381,035 New
Susquehanna International Group
54
Susquehanna International Group
Pennsylvania
$3.48M +$457K +41,557 +13%
DMKJ
55
David M. Knott Jr
$3.3M +$2.47M +224,778 +176%
Royal Bank of Canada
56
Royal Bank of Canada
Ontario, Canada
$3.29M +$3.85M +349,342 +18,185%
EAM
57
Exome Asset Management
New York
$2.89M -$318K -28,900 -9%
Aberdeen Group
58
Aberdeen Group
United Kingdom
$2.84M +$1.88M +170,993 +129%
YIH
59
Y-Intercept (HK)
Hong Kong
$2.59M +$3.05M +276,932 New
JP Morgan Chase
60
JP Morgan Chase
New York
$2.56M -$9.17M -832,933 -75%
N
61
Nuveen
North Carolina
$2.49M +$461K +41,890 +19%
SSA
62
Schonfeld Strategic Advisors
New York
$2.48M +$2.4M +218,349 +471%
UBS AM
63
UBS AM
Illinois
$2.4M +$610K +55,442 +28%
Bank of New York Mellon
64
Bank of New York Mellon
New York
$2.22M +$80.8K +7,343 +3%
Marshall Wace
65
Marshall Wace
United Kingdom
$2.17M +$2.55M +232,123 New
AQR Capital Management
66
AQR Capital Management
Connecticut
$2.16M -$1.62M -146,867 -39%
Man Group
67
Man Group
United Kingdom
$2.14M +$1.03M +94,031 +70%
Walleye Capital
68
Walleye Capital
New York
$2.12M -$1.11M -101,119 -31%
SC
69
SummitTX Capital
Texas
$1.98M +$517K +47,011 +29%
TCM
70
Tang Capital Management
California
$1.87M
VIG
71
Vienna Insurance Group
Poland
$1.87M
Macquarie Group
72
Macquarie Group
Australia
$1.69M
EGM
73
Engineers Gate Manager
New York
$1.68M +$581K +52,791 +42%
Capital Fund Management (CFM)
74
Capital Fund Management (CFM)
France
$1.67M +$1.96M +178,289 New
CSS
75
Cubist Systematic Strategies
Connecticut
$1.65M +$1.93M +175,630 +43,908%

SNDX Hedge Fund Activity: Q2 2025 in Review

216 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Syndax Pharmaceuticals (SNDX) for Q2 2025, worth a combined $953M — down 24% from $1.25B a quarter earlier.

Sellers outnumbered buyers: 32 funds closed out of SNDX and 31 opened new positions — a net loss of 1 holder — while 66 trimmed existing stakes and 86 added.

The largest buyer was BlackRock, adding an estimated $21.1M. The largest seller was Citadel Advisors, cutting an estimated $25M.

  • 216 institutional investors held Syndax Pharmaceuticals (SNDX) as of Q2 2025, down from 218 in Q1 2025.
  • Funds reported $953M of Syndax Pharmaceuticals stock for Q2 2025, down 24% quarter-over-quarter.
  • 31 funds opened new Syndax Pharmaceuticals positions in Q2 2025 and 32 closed out, a net change of -1 holder.
  • The largest Syndax Pharmaceuticals buyer in Q2 2025 was BlackRock, an estimated $21.1M added.
  • The largest Syndax Pharmaceuticals seller in Q2 2025 was Citadel Advisors, an estimated $25M sold.

Based on aggregated 13F filings for Q2 2025.