SKYE icon

Skye Bioscience

4.07 USD
-0.18
4.24%
At close Updated Sep 15, 4:00 PM EDT
Pre-market
After hours
4.18
+0.11
2.7%
1 day
-4.24%
5 days
-4.01%
1 month
15.95%
3 months
91.98%
6 months
60.87%
Year to date
42.81%
1 year
-29.83%
5 years
-67.93%
10 years
-67.93%
 

About: Skye Bioscience Inc is a pre-clinical pharmaceutical company located in San Diego, California. The company's clinical assets focus on the modulation of cannabinoid receptor 1 ("CB1") to provide novel treatments and alternatives for diseases caused by metabolic disorders, inflammation, fibrosis, and neurodegeneration, such as obesity and glaucoma. The company's Phase 2 clinical candidates include nimacimab, a negative allosteric modulating antibody that inhibits peripheral CB1 receptors, currently being developed for the treatment of obesity and SBI-100 Ophthalmic Emulsion ("SBI-100 OE"), a CB1 agonist (activator), currently being developed for the treatment of glaucoma and ocular hypertension.

Employees: 16

0
Funds holding %
of 7,463 funds
Analysts bullish %

Fund manager confidence

Based on 2025 Q2 regulatory disclosures by fund managers ($100M+ AUM)

117% more capital invested

Capital invested by funds: $39.3M [Q1] → $85.3M (+$46M) [Q2]

111% more call options, than puts

Call options by funds: $388K | Put options by funds: $184K

13.87% less ownership

Funds ownership: 79.73% [Q1] → 65.86% (-13.87%) [Q2]

19% less repeat investments, than reductions

Existing positions increased: 13 | Existing positions reduced: 16

24% less funds holding

Funds holding: 75 [Q1] → 57 (-18) [Q2]

33% less funds holding in top 10

Funds holding in top 10: 3 [Q1] → 2 (-1) [Q2]

59% less first-time investments, than exits

New positions opened: 12 | Existing positions closed: 29

Research analyst outlook

2 Wall Street Analysts provided 1 year price targets over the past 3 months

Low target
$10
146% upside
Avg. target
$12.5
207% upside
High target
$15
269% upside

2 analyst ratings

positive
100%
neutral
0%
negative
0%
Evercore ISI Group
Michael DiFiore
$10
Outperform
Initiated
15 Aug 2025
JMP Securities
Jonathan Wolleben
$15
Market Outperform
Reiterated
24 Jun 2025

Financial journalist opinion

Based on 7 articles about SKYE published over the past 30 days

Neutral
Seeking Alpha
5 days ago
Skye Bioscience, Inc. (SKYE) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript
Skye Bioscience, Inc. (NASDAQ:SKYE ) Morgan Stanley 23rd Annual Global Healthcare Conference September 10, 2025 7:00 AM EDT Company Participants Punit Dhillon - President, CEO, Secretary & Director Conference Call Participants Frank Tang - Morgan Stanley Presentation Frank Tang Managing Director Good morning, everyone. My name is Frank Tang, and I'm with the Investment Banking division at Morgan Stanley.
Skye Bioscience, Inc. (SKYE) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript
Positive
Benzinga
10 days ago
Skye Bioscience Advances Position In Competitive Obesity Market With Promising Data
On Thursday, Skye Bioscience Inc. SKYE reported positive results from two preclinical obesity studies testing nimacimab, a peripherally-acting CB1-inhibiting monoclonal antibody.
Skye Bioscience Advances Position In Competitive Obesity Market With Promising Data
Neutral
Seeking Alpha
10 days ago
Skye Bioscience, Inc. (SKYE) Virtual KOL Event Transcript
Skye Bioscience, Inc. (SKYE) Virtual KOL Event Transcript
Skye Bioscience, Inc. (SKYE) Virtual KOL Event Transcript
Neutral
GlobeNewsWire
11 days ago
Skye's CB1 Inhibitor, Nimacimab, Demonstrates Superior Weight Loss and Differentiated Mechanisms from Monlunabant, and Continues to Show Enhanced Combination with Tirzepatide with Durable Post-Treatment Weight Maintenance in DIO Model
Skye shares new preclinical DIO data at virtual KOL event Nimacimab + tirzepatide demonstrates over 40% weight loss in multiple preclinical DIO studies Nimacimab demonstrates durable post-treatment weight loss compared to tirzepatide Nimacimab reduced rebound weight gain following treatment with tirzepatide or nimacimab + tirzepatide Nimacimab outperformed monlunabant head-to-head, and is uniquely positioned as a well-tolerated therapeutic to potentially induce healthier and sustained weight loss, both as a monotherapy, combination and maintenance therapy Top-line data from Phase 2 CBeyond TM study expected to be reported in late Q3/early Q4 2025 SAN DIEGO, Sept. 04, 2025 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) (“Skye”), a clinical-stage biotechnology company focused on unlocking new therapeutic pathways for obesity and other metabolic health disorders, today reported results from two new preclinical diet induced obesity mouse (DIO) studies evaluating nimacimab, a peripherally-acting CB1-inhibiting monoclonal antibody.
Skye's CB1 Inhibitor, Nimacimab, Demonstrates Superior Weight Loss and Differentiated Mechanisms from Monlunabant, and Continues to Show Enhanced Combination with Tirzepatide with Durable Post-Treatment Weight Maintenance in DIO Model
Neutral
GlobeNewsWire
13 days ago
Skye Completes 26-week Treatment Phase in Phase 2a CBeyond™ Study
SAN DIEGO, Sept. 02, 2025 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) (“Skye”), a clinical-stage biotechnology company focused on unlocking new therapeutic pathways for obesity and other metabolic health disorders, today announced that the last patient has completed 26 weeks of treatment in the main study of its Phase 2a CBeyond™ clinical trial evaluating nimacimab, Skye's peripherally-restricted CB1 inhibitor antibody, for the treatment of obesity and overweight.
Skye Completes 26-week Treatment Phase in Phase 2a CBeyond™ Study
Neutral
GlobeNewsWire
19 days ago
Skye Bioscience to Host Virtual KOL Event and Provide Perspectives on Upcoming CBeyond™ Phase 2a Topline Clinical Data Readout
Virtual KOL event will begin at 8:00 AM ET on Thursday, September 4, 2025 Virtual KOL event will begin at 8:00 AM ET on Thursday, September 4, 2025
Skye Bioscience to Host Virtual KOL Event and Provide Perspectives on Upcoming CBeyond™ Phase 2a Topline Clinical Data Readout
Neutral
GlobeNewsWire
25 days ago
Skye Bioscience to Participate in Upcoming Investment and Medical Conferences
SAN DIEGO, Aug. 21, 2025 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) (“Skye”), a clinical-stage biotechnology company focused on unlocking new therapeutic pathways for obesity and other metabolic health disorders, today announced that it will participate in the following upcoming investment and medical conferences:
Skye Bioscience to Participate in Upcoming Investment and Medical Conferences
Neutral
Seeking Alpha
1 month ago
Skye Bioscience, Inc. (SKYE) Q2 2025 Earnings Call Transcript
Skye Bioscience, Inc. (NASDAQ:SKYE ) Q2 2025 Earnings Conference Call August 7, 2025 4:30 PM ET Company Participants Kaitlyn Melanie Arsenault - Chief Financial Officer Puneet S. Arora - Chief Medical Officer Punit S.
Skye Bioscience, Inc. (SKYE) Q2 2025 Earnings Call Transcript
Positive
The Motley Fool
1 month ago
Skye (SKYE) Q2 R&D Soars 249% No Revenue
Skye Bioscience (SKYE -8.23%), a biotechnology company developing novel obesity therapeutics, released its second quarter earnings on August 7, 2025. As in prior quarters, no commercial revenue was reported.
Skye (SKYE) Q2 R&D Soars 249% No Revenue
Neutral
GlobeNewsWire
1 month ago
Skye Bioscience Reports Second Quarter 2025 Financial Results and Business Update
SAN DIEGO, Aug. 07, 2025 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (NASDAQ: SKYE) (“Skye” or the “Company”), a clinical stage biotechnology company developing next-generation molecules that modulate G-protein-coupled receptors to treat obesity, overweight, and related conditions, today reported financial results for the second quarter ended June 30, 2025, along with key accomplishments and upcoming milestones.
Skye Bioscience Reports Second Quarter 2025 Financial Results and Business Update
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