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SAGE

Sage Therapeutics
SAGE

Delisted

SAGE was delisted on the 30th of July, 2025.

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216 hedge funds and large institutions have $2.12B invested in Sage Therapeutics in 2021 Q4 according to their latest regulatory filings, with 27 funds opening new positions, 78 increasing their positions, 74 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed

64% more call options, than puts

Call options by funds: $53.2M | Put options by funds: $32.4M

1.75% more ownership

Funds ownership: 83.45% → 85.19% (+1.7%)

5% more repeat investments, than reductions

Existing positions increased: 78 | Existing positions reduced: 74

3% less capital invested

Capital invested by funds: $2.17B → $2.12B (-$55.3M)

4% less funds holding

Funds holding: 225 → 216 (-9)

18% less first-time investments, than exits

New positions opened: 27 | Existing positions closed: 33

33% less funds holding in top 10

Funds holding in top 10: 3 → 2 (-1)

Holders
216
Holders Change
-9
Holders Change %
-4%
% of All Funds
3.32%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.03%
New
27
Increased
78
Reduced
74
Closed
33
Calls
$53.2M
Puts
$32.4M
Net Calls
+$20.9M
Net Calls Change
+$39.9M

Top Buyers

1
EC
EcoR1 Capital
California
+$39.4M
2
Citadel Advisors
Citadel Advisors
Florida
+$17.9M
3
JP Morgan Chase
JP Morgan Chase
New York
+$16.6M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$14.9M
5
First Trust Advisors
First Trust Advisors
Illinois
+$9.31M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$17.6M
2
GPP
Great Point Partners
Connecticut
-$11.9M
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$11M
4
Vanguard Group
Vanguard Group
Pennsylvania
-$10.6M
5
ACM
Asymmetry Capital Management
California
-$10.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
Wellington Management Group
1
Wellington Management Group
Massachusetts
$303M +$14.9M +356,478 +5%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$234M -$6.13M -146,510 -3%
Vanguard Group
3
Vanguard Group
Pennsylvania
$195M -$10.6M -253,028 -5%
BG
4
Bellevue Group
Switzerland
$137M +$796K +19,000 +0.6%
BlackRock
5
BlackRock
New York
$118M -$3.98M -95,118 -3%
State Street
6
State Street
Massachusetts
$92.2M +$8.06M +192,578 +10%
JP Morgan Chase
7
JP Morgan Chase
New York
$66.4M +$16.6M +397,001 +34%
T. Rowe Price Associates
8
T. Rowe Price Associates
Maryland
$60.3M +$403K +9,633 +0.7%
Citadel Advisors
9
Citadel Advisors
Florida
$46.7M +$17.9M +427,855 +64%
BC
10
Boxer Capital
California
$46.5M – – –
AG
11
Artal Group
Luxembourg
$42.5M – – –
D.E. Shaw & Co
12
D.E. Shaw & Co
New York
$42.3M -$11M -262,022 -21%
Janus Henderson Group
13
Janus Henderson Group
United Kingdom
$41.5M -$3.18M -76,011 -7%
EC
14
EcoR1 Capital
California
$40M +$39.4M +940,636 New
Geode Capital Management
15
Geode Capital Management
Massachusetts
$38.6M +$1.4M +33,424 +4%
First Trust Advisors
16
First Trust Advisors
Illinois
$34.5M +$9.31M +222,395 +38%
PAI
17
Palo Alto Investors
California
$33.3M +$6.86M +163,800 +27%
Ameriprise
18
Ameriprise
Minnesota
$33.1M +$3.82M +91,290 +13%
Deutsche Bank
19
Deutsche Bank
Germany
$25.8M -$1.04M -24,945 -4%
DTC
20
Deep Track Capital
Connecticut
$21.3M +$20.9M +500,000 New
Norges Bank
21
Norges Bank
Norway
$20.4M +$396K +9,455 +2%
AQR Capital Management
22
AQR Capital Management
Connecticut
$19.9M -$2.78M -66,333 -12%
Acadian Asset Management
23
Acadian Asset Management
Massachusetts
$19.5M +$3.28M +78,335 +21%
Goldman Sachs
24
Goldman Sachs
New York
$18.9M -$1.15M -27,535 -6%
IHAM
25
Integral Health Asset Management
New York
$17.4M +$3.77M +90,000 +28%
1
2 3 4 5

SAGE Hedge Fund Activity: Q4 2021 in Review

216 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Sage Therapeutics (SAGE) for Q4 2021, worth a combined $2.12B — down 2.5% from $2.17B a quarter earlier.

Sellers outnumbered buyers: 33 funds closed out of SAGE and 27 opened new positions — a net loss of 6 holders — while 74 trimmed existing stakes and 78 added.

The largest buyer was EcoR1 Capital, opening a new position worth an estimated $39.4M. The largest seller was Point72 Asset Management, cutting an estimated $17.6M.

  • 216 institutional investors held Sage Therapeutics (SAGE) as of Q4 2021, down from 225 in Q3 2021.
  • Funds reported $2.12B of Sage Therapeutics stock for Q4 2021, down 2.5% quarter-over-quarter.
  • 27 funds opened new Sage Therapeutics positions in Q4 2021 and 33 closed out, a net change of -6 holders.
  • The largest Sage Therapeutics buyer in Q4 2021 was EcoR1 Capital, an estimated $39.4M added.
  • The largest Sage Therapeutics seller in Q4 2021 was Point72 Asset Management, an estimated $17.6M sold.

Based on aggregated 13F filings for Q4 2021.