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SAGE

Sage Therapeutics
SAGE

Delisted

SAGE was delisted on the 30th of July, 2025.

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216 hedge funds and large institutions have $2.12B invested in Sage Therapeutics in 2021 Q4 according to their latest regulatory filings, with 27 funds opening new positions, 78 increasing their positions, 74 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed

64% more call options, than puts

Call options by funds: $53.2M | Put options by funds: $32.4M

1.75% more ownership

Funds ownership: 83.45% → 85.19% (+1.7%)

5% more repeat investments, than reductions

Existing positions increased: 78 | Existing positions reduced: 74

3% less capital invested

Capital invested by funds: $2.17B → $2.12B (-$55.3M)

4% less funds holding

Funds holding: 225 → 216 (-9)

18% less first-time investments, than exits

New positions opened: 27 | Existing positions closed: 33

33% less funds holding in top 10

Funds holding in top 10: 3 → 2 (-1)

Holders
216
Holders Change
-9
Holders Change %
-4%
% of All Funds
3.32%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.03%
New
27
Increased
78
Reduced
74
Closed
33
Calls
$53.2M
Puts
$32.4M
Net Calls
+$20.9M
Net Calls Change
+$39.9M

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$39.4M
2
Citadel Advisors
Citadel Advisors
Florida
+$17.9M
3
JP Morgan Chase
JP Morgan Chase
New York
+$16.6M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$14.9M
5
First Trust Advisors
First Trust Advisors
Illinois
+$9.31M

Top Sellers

Rank Fund Capital Flow
1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$17.6M
2
GPP
Great Point Partners
Connecticut
-$11.9M
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$11M
4
Vanguard Group
Vanguard Group
Pennsylvania
-$10.6M
5
ACM
Asymmetry Capital Management
California
-$10.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
Barclays
76
Barclays
United Kingdom
$2.69M +$539K +12,885 +26%
Invesco
77
Invesco
Georgia
$2.48M -$2.86M -68,292 -54%
CCM
78
Cinctive Capital Management
New York
$2.43M +$744K +17,779 +45%
HWAM
79
Hennion & Walsh Asset Management
New Jersey
$2.22M +$603K +14,393 +38%
Mackenzie Financial
80
Mackenzie Financial
Ontario, Canada
$2.14M +$54.4K +1,300 +3%
Hudson Bay Capital Management
81
Hudson Bay Capital Management
Connecticut
$2.13M +$1.05M +25,000 +100%
RhumbLine Advisers
82
RhumbLine Advisers
Massachusetts
$2.04M +$3.85K +92 +0.2%
Thrivent Financial for Lutherans
83
Thrivent Financial for Lutherans
Minnesota
$2M +$1.97M +47,139 New
Stifel Financial
84
Stifel Financial
Missouri
$1.93M -$439K -10,476 -19%
Two Sigma Advisers
85
Two Sigma Advisers
New York
$1.92M -$138K -3,300 -7%
Bank of Nova Scotia
86
Bank of Nova Scotia
Ontario, Canada
$1.87M +$1.84M +44,032 New
TD Asset Management
87
TD Asset Management
Ontario, Canada
$1.86M – – –
SM
88
SG3 Management
Puerto Rico
$1.81M +$251K +6,000 +16%
Federated Hermes
89
Federated Hermes
Pennsylvania
$1.68M +$229K +5,473 +16%
Robeco Institutional Asset Management
90
Robeco Institutional Asset Management
Netherlands
$1.49M +$315K +7,532 +27%
Marshall Wace
91
Marshall Wace
United Kingdom
$1.46M -$1.88M -44,834 -57%
JAM
92
Jupiter Asset Management
United Kingdom
$1.33M – – –
Bank of Montreal
93
Bank of Montreal
Ontario, Canada
$1.23M -$7.11M -169,782 -86%
CAM
94
ClariVest Asset Management
California
$1.2M -$117K -2,800 -9%
Royal Bank of Canada
95
Royal Bank of Canada
Ontario, Canada
$1.18M +$240K +5,730 +26%
Ohio Public Employees Retirement System (OPERS)
96
Ohio Public Employees Retirement System (OPERS)
Ohio
$1.18M -$43.6K -1,041 -4%
Millennium Management
97
Millennium Management
New York
$1.14M -$5.14M -122,818 -82%
GCP
98
GSA Capital Partners
United Kingdom
$1.11M +$740K +17,664 +211%
HSA
99
Hussman Strategic Advisors
Maryland
$1.11M -$2.03M -48,400 -65%
FT
100
Fiduciary Trust
Massachusetts
$1.11M -$419 -10 -0%
2 3
4
5 6

SAGE Hedge Fund Activity: Q4 2021 in Review

216 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Sage Therapeutics (SAGE) for Q4 2021, worth a combined $2.12B — down 2.5% from $2.17B a quarter earlier.

Sellers outnumbered buyers: 33 funds closed out of SAGE and 27 opened new positions — a net loss of 6 holders — while 74 trimmed existing stakes and 78 added.

The largest buyer was EcoR1 Capital, opening a new position worth an estimated $39.4M. The largest seller was Point72 Asset Management, cutting an estimated $17.6M.

  • 216 institutional investors held Sage Therapeutics (SAGE) as of Q4 2021, down from 225 in Q3 2021.
  • Funds reported $2.12B of Sage Therapeutics stock for Q4 2021, down 2.5% quarter-over-quarter.
  • 27 funds opened new Sage Therapeutics positions in Q4 2021 and 33 closed out, a net change of -6 holders.
  • The largest Sage Therapeutics buyer in Q4 2021 was EcoR1 Capital, an estimated $39.4M added.
  • The largest Sage Therapeutics seller in Q4 2021 was Point72 Asset Management, an estimated $17.6M sold.

Based on aggregated 13F filings for Q4 2021.