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Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$178M +$1.89M +38,540 +1%
BlackRock
2
BlackRock
New York
$109M +$1.62M +33,089 +2%
Artisan Partners
3
Artisan Partners
Wisconsin
$97.8M -$24.5M -499,931 -21%
Lord, Abbett & Co
4
Lord, Abbett & Co
New Jersey
$91.4M -$10M -204,610 -10%
Vanguard Group
5
Vanguard Group
Pennsylvania
$78.6M +$1.99M +40,500 +3%
Fidelity Investments
6
Fidelity Investments
Massachusetts
$68M +$6.51M +132,684 +11%
Morgan Stanley
7
Morgan Stanley
New York
$58.1M +$2.58M +52,589 +5%
SPPAM
8
Summit Partners Public Asset Management
Massachusetts
$40.4M +$24.4M +496,648 +173%
T. Rowe Price Investment Management
9
T. Rowe Price Investment Management
Maryland
$39.8M -$9.12M -185,886 -19%
Deutsche Bank
10
Deutsche Bank
Germany
$39.7M +$3.12M +63,640 +9%
Invesco
11
Invesco
Georgia
$39.7M +$25.8M +525,138 +215%
Nuveen
12
Nuveen
North Carolina
$38.4M +$2.44M +49,688 +7%
State Street
13
State Street
Massachusetts
$34.6M -$1.6M -32,684 -5%
Bank of America
14
Bank of America
North Carolina
$32.4M +$4.4M +89,717 +17%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$29.7M +$842K +17,153 +3%
NCGI
16
Next Century Growth Investors
Minnesota
$26.3M -$7.19M -146,508 -22%
GGHC
17
Gilder Gagnon Howe & Co
New York
$23.7M +$15M +306,509 +202%
ACM
18
Atika Capital Management
New York
$21.4M -$1.47M -30,000 -7%
PHP
19
Parkman Healthcare Partners
Connecticut
$21.3M -$4.94M -100,600 -20%
DCM
20
Driehaus Capital Management
Illinois
$20.8M -$6.16M -125,425 -24%
Two Sigma Investments
21
Two Sigma Investments
New York
$19.8M +$5.05M +102,819 +37%
Voloridge Investment Management
22
Voloridge Investment Management
Florida
$19.4M +$3.85M +78,380 +26%
NSGL
23
No Street GP LP
California
$19.3M -$2.45M -50,000 -12%
Two Sigma Advisers
24
Two Sigma Advisers
New York
$18.8M +$2.88M +58,700 +19%
Millennium Management
25
Millennium Management
New York
$18.3M +$1.58M +32,150 +10%
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