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Royalty Pharma
RPRX

447 hedge funds and large institutions have $10.1B invested in Royalty Pharma in 2025 Q1 according to their latest regulatory filings, with 84 funds opening new positions, 160 increasing their positions, 149 reducing their positions, and 50 closing their positions.

New
Increased
Maintained
Reduced
Closed

160% more call options, than puts

Call options by funds: $89M | Put options by funds: $34.2M

68% more first-time investments, than exits

New positions opened: 84 | Existing positions closed: 50

22% more capital invested

Capital invested by funds: $8.21B → $10.1B (+$1.84B)

7% more funds holding

Funds holding: 416 → 447 (+31)

2.07% more ownership

Funds ownership: 72.43% → 74.49% (+2.1%)

7% more repeat investments, than reductions

Existing positions increased: 160 | Existing positions reduced: 149

22% less funds holding in top 10

Funds holding in top 10: 9 → 7 (-2)

Holders
447
Holders Change
+31
Holders Change %
+7.45%
% of All Funds
5.99%
Holding in Top 10
7
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-22.22%
% of All Funds
0.09%
New
84
Increased
160
Reduced
149
Closed
50
Calls
$89M
Puts
$34.2M
Net Calls
+$54.8M
Net Calls Change
+$39.9M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$413M
2
CIA
Caledonia Investments (Australia)
Australia
+$162M
3
Victory Capital Management
Victory Capital Management
Texas
+$83.8M
4
Morgan Stanley
Morgan Stanley
New York
+$47.5M
5
Los Angeles Capital Management
Los Angeles Capital Management
California
+$33M

Top Sellers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$340M
2
Millennium Management
Millennium Management
New York
-$66.8M
3
SGA
Siguler Guff Advisers
New York
-$60.4M
4
Deutsche Bank
Deutsche Bank
Germany
-$56.3M
5
Viking Global Investors
Viking Global Investors
Connecticut
-$52.1M
Name Holding Trade Value Shares
Change 		Change in
Stake
PA
301
Profund Advisors
Maryland
$362K -$131K -4,128 -26%
SOW
302
State of Wyoming
Wyoming
$356K -$116K -3,652 -24%
GFM
303
GF Fund Management
China
$354K +$64.9K +2,048 +22%
Walleye Capital
304
Walleye Capital
New York
$354K -$436K -13,759 -55%
PWP
305
Phillips Wealth Planners
Mississippi
$353K +$350K +11,051 New
OIS
306
OneAscent Investment Solutions
Alabama
$352K +$358K +11,295 New
AFCM
307
Applied Finance Capital Management
Puerto Rico
$351K +$10.4K +329 +3%
KRSITF
308
Kentucky Retirement Systems Insurance Trust Fund
Kentucky
$349K +$355K +11,210 New
CIBC World Market
309
CIBC World Market
Ontario, Canada
$343K -$579K -18,256 -62%
IMCOOI
310
Investment Management Corp of Ontario (IMCO)
Canada
$331K – – –
O
311
Ossiam
France
$328K -$118K -3,716 -26%
Holocene Advisors
312
Holocene Advisors
New York
$327K +$333K +10,509 New
RIM
313
Rakuten Investment Management
Japan
$327K +$330K +10,420 New
IQI
314
Integrated Quantitative Investments
Washington
$318K -$162K -5,100 -33%
Rafferty Asset Management
315
Rafferty Asset Management
New York
$309K -$132K -4,156 -30%
II
316
Inspire Investing
Idaho
$309K -$7.64K -241 -2%
Cetera Investment Advisers
317
Cetera Investment Advisers
Illinois
$306K +$311K +9,826 New
1IA
318
1834 Investment Advisors
Wisconsin
$296K – – –
AI
319
Atria Investments
North Carolina
$290K -$423K -13,331 -59%
SAM
320
Sectoral Asset Management
Quebec, Canada
$289K +$65.9K +2,080 +29%
BCI
321
Brinker Capital Investments
Pennsylvania
$286K +$291K +9,189 New
OPS
322
Orion Portfolio Solutions
Nebraska
$286K +$291K +9,189 New
YCM
323
Yousif Capital Management
Michigan
$275K +$280K +8,824 New
Focus Partners Wealth
324
Focus Partners Wealth
Massachusetts
$264K +$269K +8,473 New
Jones Financial Companies
325
Jones Financial Companies
Missouri
$257K +$39.4K +1,243 +18%
11 12
13
14 15

RPRX Hedge Fund Activity: Q1 2025 in Review

447 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Royalty Pharma (RPRX) for Q1 2025, worth a combined $10.1B — up 22% from $8.21B a quarter earlier.

Buyers outnumbered sellers: 84 funds opened new RPRX positions and 50 closed out — a net gain of 34 holders — while 160 added to existing stakes and 149 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $413M. The largest seller was Adage Capital Partners, cutting an estimated $340M.

  • 447 institutional investors held Royalty Pharma (RPRX) as of Q1 2025, up from 416 in Q4 2024.
  • Funds reported $10.1B of Royalty Pharma stock for Q1 2025, up 22% quarter-over-quarter.
  • 84 funds opened new Royalty Pharma positions in Q1 2025 and 50 closed out, a net change of +34 holders.
  • The largest Royalty Pharma buyer in Q1 2025 was Fidelity Investments, an estimated $413M added.
  • The largest Royalty Pharma seller in Q1 2025 was Adage Capital Partners, an estimated $340M sold.

Based on aggregated 13F filings for Q1 2025.